node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Apcdd1 | Axin2 | ENSMUSP00000157539 | ENSMUSP00000051331 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. | Axin-2; Inhibitor of the Wnt signaling pathway. Down-regulates beta- catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. | 0.634 |
Apcdd1 | Cdsn | ENSMUSP00000157539 | ENSMUSP00000048596 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.673 |
Apcdd1 | Dsg4 | ENSMUSP00000157539 | ENSMUSP00000019426 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | 0.646 |
Apcdd1 | Eps8l3 | ENSMUSP00000157539 | ENSMUSP00000042004 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. | Epidermal growth factor receptor kinase substrate 8-like protein 3. | 0.638 |
Apcdd1 | Lpar6 | ENSMUSP00000157539 | ENSMUSP00000042327 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. | Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity). | 0.626 |
Apcdd1 | Lrp5 | ENSMUSP00000157539 | ENSMUSP00000025856 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. | Low-density lipoprotein receptor-related protein 5; Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanist [...] | 0.946 |
Apcdd1 | Notum | ENSMUSP00000157539 | ENSMUSP00000101783 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. | Palmitoleoyl-protein carboxylesterase NOTUM; Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. | 0.561 |
Apcdd1 | Snrpe | ENSMUSP00000157539 | ENSMUSP00000128400 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. | Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. | 0.651 |
Apcdd1 | Wnt3 | ENSMUSP00000157539 | ENSMUSP00000000127 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. | Proto-oncogene Wnt-3; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge and for normal embryonic limb development. | 0.560 |
Apcdd1 | Wnt3a | ENSMUSP00000157539 | ENSMUSP00000010044 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. | Protein Wnt-3a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube. Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro). | 0.846 |
Axin2 | Apcdd1 | ENSMUSP00000051331 | ENSMUSP00000157539 | Axin-2; Inhibitor of the Wnt signaling pathway. Down-regulates beta- catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. | 0.634 |
Axin2 | Lrp5 | ENSMUSP00000051331 | ENSMUSP00000025856 | Axin-2; Inhibitor of the Wnt signaling pathway. Down-regulates beta- catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. | Low-density lipoprotein receptor-related protein 5; Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanist [...] | 0.870 |
Axin2 | Notum | ENSMUSP00000051331 | ENSMUSP00000101783 | Axin-2; Inhibitor of the Wnt signaling pathway. Down-regulates beta- catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. | Palmitoleoyl-protein carboxylesterase NOTUM; Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. | 0.646 |
Axin2 | Wnt3 | ENSMUSP00000051331 | ENSMUSP00000000127 | Axin-2; Inhibitor of the Wnt signaling pathway. Down-regulates beta- catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. | Proto-oncogene Wnt-3; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge and for normal embryonic limb development. | 0.730 |
Axin2 | Wnt3a | ENSMUSP00000051331 | ENSMUSP00000010044 | Axin-2; Inhibitor of the Wnt signaling pathway. Down-regulates beta- catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. | Protein Wnt-3a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube. Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro). | 0.873 |
Cdsn | Apcdd1 | ENSMUSP00000048596 | ENSMUSP00000157539 | Corneodesmosin; Important for the epidermal barrier integrity. | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. | 0.673 |
Cdsn | Dsg4 | ENSMUSP00000048596 | ENSMUSP00000019426 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | 0.679 |
Cdsn | Eps8l3 | ENSMUSP00000048596 | ENSMUSP00000042004 | Corneodesmosin; Important for the epidermal barrier integrity. | Epidermal growth factor receptor kinase substrate 8-like protein 3. | 0.644 |
Cdsn | Lpar6 | ENSMUSP00000048596 | ENSMUSP00000042327 | Corneodesmosin; Important for the epidermal barrier integrity. | Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity). | 0.617 |
Cdsn | Snrpe | ENSMUSP00000048596 | ENSMUSP00000128400 | Corneodesmosin; Important for the epidermal barrier integrity. | Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. | 0.662 |