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Gpx4 protein (mouse) - STRING interaction network
"Gpx4" - Phospholipid hydroperoxide glutathione peroxidase, nuclear in Mus musculus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Gpx4Phospholipid hydroperoxide glutathione peroxidase, nuclear; Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Stabilizes the condensed chromatin in sperm nuclei and is necessary for male fertility (253 aa)    
Predicted Functional Partners:
Gsr
Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol (500 aa)
   
 
  0.986
Gss
Glutathione synthetase; Belongs to the eukaryotic GSH synthase family (474 aa)
         
  0.953
Sod2
Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems (222 aa)
     
 
  0.920
Ggt7
Glutathione hydrolase 7; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family (662 aa)
     
 
  0.918
Gstm5
Glutathione S-transferase Mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family (224 aa)
     
 
  0.916
Ggt1
Glutathione hydrolase 1 proenzyme; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione ( [...] (568 aa)
     
 
  0.913
Ggt5
Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4) (573 aa)
     
 
  0.913
Ggt6
Glutathione hydrolase 6; Cleaves glutathione conjugates (497 aa)
     
 
  0.912
Cat
Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family (527 aa)
     
 
  0.907
Sod1
Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family (154 aa)
   
 
  0.895
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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