node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actl7b | Arrdc5 | ENSMUSP00000092693 | ENSMUSP00000094906 | Actin-like protein 7B; Belongs to the actin family. | Arrestin domain-containing protein 5; Belongs to the arrestin family. | 0.549 |
Actl7b | Meig1 | ENSMUSP00000092693 | ENSMUSP00000070310 | Actin-like protein 7B; Belongs to the actin family. | Meiosis-expressed gene 1 protein; Essential for spermiogenesis; Belongs to the MEIG1 family. | 0.538 |
Actl7b | Odf4 | ENSMUSP00000092693 | ENSMUSP00000040050 | Actin-like protein 7B; Belongs to the actin family. | Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton. | 0.590 |
Actl7b | Tex38 | ENSMUSP00000092693 | ENSMUSP00000102131 | Actin-like protein 7B; Belongs to the actin family. | Testis-expressed protein 38. | 0.541 |
Arrdc5 | Actl7b | ENSMUSP00000094906 | ENSMUSP00000092693 | Arrestin domain-containing protein 5; Belongs to the arrestin family. | Actin-like protein 7B; Belongs to the actin family. | 0.549 |
Arrdc5 | Meig1 | ENSMUSP00000094906 | ENSMUSP00000070310 | Arrestin domain-containing protein 5; Belongs to the arrestin family. | Meiosis-expressed gene 1 protein; Essential for spermiogenesis; Belongs to the MEIG1 family. | 0.540 |
Arrdc5 | Nedd4 | ENSMUSP00000094906 | ENSMUSP00000034740 | Arrestin domain-containing protein 5; Belongs to the arrestin family. | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1. Predominantly involved in ubiquiti [...] | 0.711 |
Arrdc5 | Odf4 | ENSMUSP00000094906 | ENSMUSP00000040050 | Arrestin domain-containing protein 5; Belongs to the arrestin family. | Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton. | 0.518 |
Arrdc5 | Sag | ENSMUSP00000094906 | ENSMUSP00000076948 | Arrestin domain-containing protein 5; Belongs to the arrestin family. | S-arrestin; Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells ; Belongs to the arrestin family. | 0.523 |
Arrdc5 | Tex38 | ENSMUSP00000094906 | ENSMUSP00000102131 | Arrestin domain-containing protein 5; Belongs to the arrestin family. | Testis-expressed protein 38. | 0.572 |
Arrdc5 | Txnip | ENSMUSP00000094906 | ENSMUSP00000102710 | Arrestin domain-containing protein 5; Belongs to the arrestin family. | Thioredoxin-interacting protein; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and co [...] | 0.636 |
Arrdc5 | Vps26c | ENSMUSP00000094906 | ENSMUSP00000023615 | Arrestin domain-containing protein 5; Belongs to the arrestin family. | Vacuolar protein sorting-associated protein 26C; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of nu [...] | 0.628 |
Arrdc5 | Wwp2 | ENSMUSP00000094906 | ENSMUSP00000132224 | Arrestin domain-containing protein 5; Belongs to the arrestin family. | NEDD4-like E3 ubiquitin-protein ligase WWP2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; regulates POU5F1 protein level during differentiation of embryonal carcinoma cells (ECCs) but not in undifferentiated ECCs and embryonic stem cells (ESCs). Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits acti [...] | 0.648 |
Arrdc5 | Znrf1 | ENSMUSP00000094906 | ENSMUSP00000133309 | Arrestin domain-containing protein 5; Belongs to the arrestin family. | E3 ubiquitin-protein ligase ZNRF1; E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes Wallerian degeneration, a neurodegeneration disorder, by mediating 'Lys-48'- linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation [...] | 0.563 |
Meig1 | Actl7b | ENSMUSP00000070310 | ENSMUSP00000092693 | Meiosis-expressed gene 1 protein; Essential for spermiogenesis; Belongs to the MEIG1 family. | Actin-like protein 7B; Belongs to the actin family. | 0.538 |
Meig1 | Arrdc5 | ENSMUSP00000070310 | ENSMUSP00000094906 | Meiosis-expressed gene 1 protein; Essential for spermiogenesis; Belongs to the MEIG1 family. | Arrestin domain-containing protein 5; Belongs to the arrestin family. | 0.540 |
Meig1 | Odf4 | ENSMUSP00000070310 | ENSMUSP00000040050 | Meiosis-expressed gene 1 protein; Essential for spermiogenesis; Belongs to the MEIG1 family. | Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton. | 0.550 |
Meig1 | Tex38 | ENSMUSP00000070310 | ENSMUSP00000102131 | Meiosis-expressed gene 1 protein; Essential for spermiogenesis; Belongs to the MEIG1 family. | Testis-expressed protein 38. | 0.538 |
Nedd4 | Arrdc5 | ENSMUSP00000034740 | ENSMUSP00000094906 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1. Predominantly involved in ubiquiti [...] | Arrestin domain-containing protein 5; Belongs to the arrestin family. | 0.711 |
Nedd4 | Sag | ENSMUSP00000034740 | ENSMUSP00000076948 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1. Predominantly involved in ubiquiti [...] | S-arrestin; Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells ; Belongs to the arrestin family. | 0.550 |