STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmc5Transmembrane channel-like protein 5; Probable ion channel; Belongs to the TMC family. (967 aa)    
Predicted Functional Partners:
Kcnh8
Potassium voltage-gated channel subfamily H member 8; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly (By similarity); Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily.
   
  
 0.563
Wscd1
WSC domain-containing protein 1; Belongs to the WSCD family.
    
 
 0.556
Lrrc71
Leucine-rich repeat-containing protein 71.
    
 
 0.533
Tmem221
Transmembrane protein 221.
      
 0.532
Tmem191c
Transmembrane protein 191C; Belongs to the TMEM191 family.
      
 0.523
Gpr137c
G protein-coupled receptor 137C; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes.
      
 0.502
Tmem211
Transmembrane protein 211.
      
 0.500
Adamts12
A disintegrin and metalloproteinase with thrombospondin motifs 12; Metalloprotease that plays a role in the degradation of COMP (By similarity). Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties (By similarity).
      
 0.499
Ankub1
Protein ANKUB1.
      
 0.488
Tbc1d14
TBC1 domain family member 14; Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy.
      
 0.477
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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