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Hbb-b2 protein (mouse) - STRING interaction network
"Hbb-b2" - Hemoglobin, beta adult minor chain in Mus musculus
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Hbb-b2Hemoglobin, beta adult minor chain; Involved in oxygen transport from the lung to the various peripheral tissues (147 aa)    
Predicted Functional Partners:
Hba-a1
Hemoglobin alpha, adult chain 1; Involved in oxygen transport from the lung to the various peripheral tissues (142 aa)
     
0.992
Hba-a2
Hemoglobin alpha, adult chain 2 (142 aa)
     
 
0.958
Hbb-b1
Hemoglobin, beta adult major chain (147 aa)
     
 
0.820
Hp
Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By si [...] (347 aa)
       
 
  0.747
Hba-x
Hemoglobin X, alpha-like embryonic chain in Hba complex; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin (142 aa)
       
0.729
Alas2
Aminolevulinic acid synthase 2, erythroid (587 aa)
     
   
  0.658
Hadha
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit; Bifunctional subunit (763 aa)
       
  0.623
B2m
Beta-2 microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (119 aa)
       
 
  0.592
Aifm3
Apoptosis-inducing factor, mitochondrion-associated 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential (By similarity) (598 aa)
     
   
  0.583
Aldh1a7
Aldehyde dehydrogenase family 1, subfamily A7; Can oxidize benzaldehyde, propionaldehyde and acetaldehyde (By similarity). No detectable activity with retinal (501 aa)
     
 
  0.557
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mice, mouse, nude mice, transgenic mice
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