node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cd44 | Col6a6 | ENSMUSP00000005218 | ENSMUSP00000096040 | CD44 antigen; Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its c [...] | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | 0.902 |
Cd44 | Itga6 | ENSMUSP00000005218 | ENSMUSP00000107729 | CD44 antigen; Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its c [...] | Integrin alpha-6 heavy chain; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (By similarity). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGA6:ITGB4 binds to IGF2 and this [...] | 0.738 |
Cd44 | Itgb4 | ENSMUSP00000005218 | ENSMUSP00000127604 | CD44 antigen; Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its c [...] | Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. | 0.464 |
Cd44 | Itgb8 | ENSMUSP00000005218 | ENSMUSP00000026360 | CD44 antigen; Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its c [...] | Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Required during vasculogenesis. | 0.477 |
Col6a6 | Cd44 | ENSMUSP00000096040 | ENSMUSP00000005218 | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | CD44 antigen; Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its c [...] | 0.902 |
Col6a6 | Gp6 | ENSMUSP00000096040 | ENSMUSP00000145740 | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Platelet glycoprotein VI; Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. | 0.910 |
Col6a6 | Itga11 | ENSMUSP00000096040 | ENSMUSP00000034774 | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen. Belongs to the integrin alpha chain family. | 0.719 |
Col6a6 | Itga6 | ENSMUSP00000096040 | ENSMUSP00000107729 | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin alpha-6 heavy chain; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (By similarity). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGA6:ITGB4 binds to IGF2 and this [...] | 0.744 |
Col6a6 | Itga7 | ENSMUSP00000096040 | ENSMUSP00000096712 | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin alpha-7 heavy chain; Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Mice carrying a ITGA7 null allele are viable and fertile, but show progressive muscular dystrophy starting soon after birth, but with a distinct variabi [...] | 0.735 |
Col6a6 | Itga8 | ENSMUSP00000096040 | ENSMUSP00000028106 | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. | 0.746 |
Col6a6 | Itga9 | ENSMUSP00000096040 | ENSMUSP00000044227 | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin alpha-9; Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D- G-I-E-L in cytotactin. | 0.775 |
Col6a6 | Itgb4 | ENSMUSP00000096040 | ENSMUSP00000127604 | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. | 0.718 |
Col6a6 | Itgb6 | ENSMUSP00000096040 | ENSMUSP00000054944 | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. | 0.728 |
Col6a6 | Itgb8 | ENSMUSP00000096040 | ENSMUSP00000026360 | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Required during vasculogenesis. | 0.716 |
Gp6 | Col6a6 | ENSMUSP00000145740 | ENSMUSP00000096040 | Platelet glycoprotein VI; Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | 0.910 |
Itga11 | Col6a6 | ENSMUSP00000034774 | ENSMUSP00000096040 | Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen. Belongs to the integrin alpha chain family. | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | 0.719 |
Itga11 | Itga6 | ENSMUSP00000034774 | ENSMUSP00000107729 | Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen. Belongs to the integrin alpha chain family. | Integrin alpha-6 heavy chain; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (By similarity). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGA6:ITGB4 binds to IGF2 and this [...] | 0.846 |
Itga11 | Itga7 | ENSMUSP00000034774 | ENSMUSP00000096712 | Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen. Belongs to the integrin alpha chain family. | Integrin alpha-7 heavy chain; Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Mice carrying a ITGA7 null allele are viable and fertile, but show progressive muscular dystrophy starting soon after birth, but with a distinct variabi [...] | 0.777 |
Itga11 | Itga8 | ENSMUSP00000034774 | ENSMUSP00000028106 | Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen. Belongs to the integrin alpha chain family. | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. | 0.642 |
Itga11 | Itga9 | ENSMUSP00000034774 | ENSMUSP00000044227 | Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen. Belongs to the integrin alpha chain family. | Integrin alpha-9; Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D- G-I-E-L in cytotactin. | 0.622 |