node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ankrd16 | Cdkn2c | ENSMUSP00000052056 | ENSMUSP00000095534 | Ankyrin repeat domain-containing protein 16; Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides. | Cyclin-dependent kinase 4 inhibitor C; Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | 0.467 |
Ankrd16 | Gabpb2 | ENSMUSP00000052056 | ENSMUSP00000121283 | Ankyrin repeat domain-containing protein 16; Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides. | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | 0.466 |
Casp2 | Gabpb2 | ENSMUSP00000031895 | ENSMUSP00000121283 | Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (By similarity). | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | 0.496 |
Cdkn2c | Ankrd16 | ENSMUSP00000095534 | ENSMUSP00000052056 | Cyclin-dependent kinase 4 inhibitor C; Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | Ankyrin repeat domain-containing protein 16; Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides. | 0.467 |
Cdkn2c | Gabpb2 | ENSMUSP00000095534 | ENSMUSP00000121283 | Cyclin-dependent kinase 4 inhibitor C; Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | 0.475 |
Ctsb | Gabpb2 | ENSMUSP00000006235 | ENSMUSP00000121283 | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | 0.491 |
Gabpa | Gabpb2 | ENSMUSP00000009120 | ENSMUSP00000121283 | GA-binding protein alpha chain; Transcription factor capable of interacting with purine rich repeats (GA repeats); Belongs to the ETS family. | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | 0.675 |
Gabpb2 | Ankrd16 | ENSMUSP00000121283 | ENSMUSP00000052056 | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | Ankyrin repeat domain-containing protein 16; Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides. | 0.466 |
Gabpb2 | Casp2 | ENSMUSP00000121283 | ENSMUSP00000031895 | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (By similarity). | 0.496 |
Gabpb2 | Cdkn2c | ENSMUSP00000121283 | ENSMUSP00000095534 | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | Cyclin-dependent kinase 4 inhibitor C; Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | 0.475 |
Gabpb2 | Ctsb | ENSMUSP00000121283 | ENSMUSP00000006235 | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. | 0.491 |
Gabpb2 | Gabpa | ENSMUSP00000121283 | ENSMUSP00000009120 | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | GA-binding protein alpha chain; Transcription factor capable of interacting with purine rich repeats (GA repeats); Belongs to the ETS family. | 0.675 |
Gabpb2 | Gm31371 | ENSMUSP00000121283 | ENSMUSP00000148655 | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | Predicted gene, 31371. | 0.511 |
Gabpb2 | Gm7697 | ENSMUSP00000121283 | ENSMUSP00000144181 | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | Predicted gene 7697. | 0.516 |
Gabpb2 | Gm9495 | ENSMUSP00000121283 | ENSMUSP00000144411 | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | Predicted gene 9495. | 0.516 |
Gabpb2 | Smim7 | ENSMUSP00000121283 | ENSMUSP00000127441 | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | Small integral membrane protein 7. | 0.560 |
Gabpb2 | Trp63 | ENSMUSP00000121283 | ENSMUSP00000110965 | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | Tumor protein 63; Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the [...] | 0.516 |
Gm31371 | Gabpb2 | ENSMUSP00000148655 | ENSMUSP00000121283 | Predicted gene, 31371. | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | 0.511 |
Gm7697 | Gabpb2 | ENSMUSP00000144181 | ENSMUSP00000121283 | Predicted gene 7697. | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | 0.516 |
Gm9495 | Gabpb2 | ENSMUSP00000144411 | ENSMUSP00000121283 | Predicted gene 9495. | GA-binding protein subunit beta-2; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA. | 0.516 |