node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Casp14 | Cdsn | ENSMUSP00000005488 | ENSMUSP00000048596 | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.571 |
Casp14 | Dsc1 | ENSMUSP00000005488 | ENSMUSP00000042303 | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | 0.583 |
Casp14 | Dsg1a | ENSMUSP00000005488 | ENSMUSP00000076393 | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.548 |
Casp14 | Dsg1b | ENSMUSP00000005488 | ENSMUSP00000076026 | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | Desmoglein-1-beta; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.473 |
Casp14 | Dsg1c | ENSMUSP00000005488 | ENSMUSP00000054799 | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | Desmoglein-1-gamma; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.462 |
Casp14 | Flg2 | ENSMUSP00000005488 | ENSMUSP00000096482 | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis; Belongs to the S100-fused protein family. | 0.610 |
Casp14 | Lor | ENSMUSP00000005488 | ENSMUSP00000052128 | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | Loricrin; Major keratinocyte cell envelope protein. | 0.727 |
Casp14 | Tgm3 | ENSMUSP00000005488 | ENSMUSP00000105928 | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cros [...] | 0.807 |
Cdsn | Casp14 | ENSMUSP00000048596 | ENSMUSP00000005488 | Corneodesmosin; Important for the epidermal barrier integrity. | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | 0.571 |
Cdsn | Dsc1 | ENSMUSP00000048596 | ENSMUSP00000042303 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | 0.989 |
Cdsn | Dsg1a | ENSMUSP00000048596 | ENSMUSP00000076393 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.986 |
Cdsn | Dsg1b | ENSMUSP00000048596 | ENSMUSP00000076026 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmoglein-1-beta; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.986 |
Cdsn | Dsg1c | ENSMUSP00000048596 | ENSMUSP00000054799 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmoglein-1-gamma; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.986 |
Cdsn | Flg2 | ENSMUSP00000048596 | ENSMUSP00000096482 | Corneodesmosin; Important for the epidermal barrier integrity. | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis; Belongs to the S100-fused protein family. | 0.560 |
Cdsn | Lor | ENSMUSP00000048596 | ENSMUSP00000052128 | Corneodesmosin; Important for the epidermal barrier integrity. | Loricrin; Major keratinocyte cell envelope protein. | 0.774 |
Cdsn | Sprr4 | ENSMUSP00000048596 | ENSMUSP00000051559 | Corneodesmosin; Important for the epidermal barrier integrity. | Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification (By similarity). | 0.454 |
Cdsn | Tgm3 | ENSMUSP00000048596 | ENSMUSP00000105928 | Corneodesmosin; Important for the epidermal barrier integrity. | Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cros [...] | 0.739 |
Dsc1 | Casp14 | ENSMUSP00000042303 | ENSMUSP00000005488 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | 0.583 |
Dsc1 | Cdsn | ENSMUSP00000042303 | ENSMUSP00000048596 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.989 |
Dsc1 | Dsg1a | ENSMUSP00000042303 | ENSMUSP00000076393 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.993 |