node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gkn2 | Tsc22d2 | ENSMUSP00000032128 | ENSMUSP00000096688 | Gastrokine-2. | TSC22 domain family, member 2. | 0.490 |
Nrbp1 | Tsc22d2 | ENSMUSP00000143872 | ENSMUSP00000096688 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. | TSC22 domain family, member 2. | 0.849 |
Nrbp1 | Tsc22d3 | ENSMUSP00000143872 | ENSMUSP00000108620 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding [...] | 0.581 |
Stac2 | Tsc22d2 | ENSMUSP00000017544 | ENSMUSP00000096688 | SH3 and cysteine-rich domain-containing protein 2; Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. | TSC22 domain family, member 2. | 0.579 |
Tbl2 | Tsc22d2 | ENSMUSP00000115011 | ENSMUSP00000096688 | Transducin beta-like protein 2. | TSC22 domain family, member 2. | 0.495 |
Tbl2 | Ube4a | ENSMUSP00000115011 | ENSMUSP00000112632 | Transducin beta-like protein 2. | Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. | 0.474 |
Tsc22d2 | Gkn2 | ENSMUSP00000096688 | ENSMUSP00000032128 | TSC22 domain family, member 2. | Gastrokine-2. | 0.490 |
Tsc22d2 | Nrbp1 | ENSMUSP00000096688 | ENSMUSP00000143872 | TSC22 domain family, member 2. | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. | 0.849 |
Tsc22d2 | Stac2 | ENSMUSP00000096688 | ENSMUSP00000017544 | TSC22 domain family, member 2. | SH3 and cysteine-rich domain-containing protein 2; Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. | 0.579 |
Tsc22d2 | Tbl2 | ENSMUSP00000096688 | ENSMUSP00000115011 | TSC22 domain family, member 2. | Transducin beta-like protein 2. | 0.495 |
Tsc22d2 | Tsc22d3 | ENSMUSP00000096688 | ENSMUSP00000108620 | TSC22 domain family, member 2. | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding [...] | 0.508 |
Tsc22d2 | Ube4a | ENSMUSP00000096688 | ENSMUSP00000112632 | TSC22 domain family, member 2. | Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. | 0.480 |
Tsc22d2 | Wdr77 | ENSMUSP00000096688 | ENSMUSP00000010278 | TSC22 domain family, member 2. | Methylosome protein 50; Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-contain [...] | 0.518 |
Tsc22d2 | Zc3h4 | ENSMUSP00000096688 | ENSMUSP00000096386 | TSC22 domain family, member 2. | Zinc finger CCCH domain-containing protein 4. | 0.459 |
Tsc22d2 | Zfp655 | ENSMUSP00000096688 | ENSMUSP00000128969 | TSC22 domain family, member 2. | Zinc finger protein 655. | 0.459 |
Tsc22d2 | Zkscan7 | ENSMUSP00000096688 | ENSMUSP00000071695 | TSC22 domain family, member 2. | Zinc finger with KRAB and SCAN domains 7. | 0.472 |
Tsc22d3 | Nrbp1 | ENSMUSP00000108620 | ENSMUSP00000143872 | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding [...] | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. | 0.581 |
Tsc22d3 | Tsc22d2 | ENSMUSP00000108620 | ENSMUSP00000096688 | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding [...] | TSC22 domain family, member 2. | 0.508 |
Ube4a | Tbl2 | ENSMUSP00000112632 | ENSMUSP00000115011 | Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. | Transducin beta-like protein 2. | 0.474 |
Ube4a | Tsc22d2 | ENSMUSP00000112632 | ENSMUSP00000096688 | Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. | TSC22 domain family, member 2. | 0.480 |