node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cck | Ccl11 | ENSMUSP00000149679 | ENSMUSP00000000342 | Cholecystokinin-12; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family. | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils; Belongs to the intercrine beta (chemokine CC) family. | 0.489 |
Cck | Ccl28 | ENSMUSP00000149679 | ENSMUSP00000096847 | Cholecystokinin-12; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family. | C-C motif chemokine 28; Chemotactic for resting CD4, CD8 T-cells and eosinophils (By similarity). Binds to CCR10 and induces calcium mobilization in a dose- dependent manner. | 0.986 |
Ccl11 | Cck | ENSMUSP00000000342 | ENSMUSP00000149679 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils; Belongs to the intercrine beta (chemokine CC) family. | Cholecystokinin-12; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family. | 0.489 |
Ccl11 | Ccl26 | ENSMUSP00000000342 | ENSMUSP00000091779 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils; Belongs to the intercrine beta (chemokine CC) family. | Chemokine (C-C motif) ligand 26. | 0.992 |
Ccl11 | Ccl28 | ENSMUSP00000000342 | ENSMUSP00000096847 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils; Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine 28; Chemotactic for resting CD4, CD8 T-cells and eosinophils (By similarity). Binds to CCR10 and induces calcium mobilization in a dose- dependent manner. | 0.972 |
Ccl11 | Ccl5 | ENSMUSP00000000342 | ENSMUSP00000039600 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils; Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.971 |
Ccl11 | Ccr10 | ENSMUSP00000000342 | ENSMUSP00000062588 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils; Belongs to the intercrine beta (chemokine CC) family. | C-C chemokine receptor type 10; Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level. | 0.748 |
Ccl11 | Cxcl10 | ENSMUSP00000000342 | ENSMUSP00000047646 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils; Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C- dependent pathway, an increa [...] | 0.983 |
Ccl11 | Cxcl12 | ENSMUSP00000000342 | ENSMUSP00000072800 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils; Belongs to the intercrine beta (chemokine CC) family. | Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (By similarity). Acts as a positive regulator of monocyte migrat [...] | 0.955 |
Ccl11 | Cxcl17 | ENSMUSP00000000342 | ENSMUSP00000144096 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils; Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 17; Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C- X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions; Belongs to the intercrine alpha (chemokine CxC) family. | 0.710 |
Ccl11 | Cxcl9 | ENSMUSP00000000342 | ENSMUSP00000108716 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils; Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 9; May be a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. | 0.975 |
Ccl11 | Ppbp | ENSMUSP00000000342 | ENSMUSP00000031319 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils; Belongs to the intercrine beta (chemokine CC) family. | Chemokine subfamily B Cys-X-Cys. | 0.881 |
Ccl26 | Ccl11 | ENSMUSP00000091779 | ENSMUSP00000000342 | Chemokine (C-C motif) ligand 26. | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils; Belongs to the intercrine beta (chemokine CC) family. | 0.992 |
Ccl26 | Ccl28 | ENSMUSP00000091779 | ENSMUSP00000096847 | Chemokine (C-C motif) ligand 26. | C-C motif chemokine 28; Chemotactic for resting CD4, CD8 T-cells and eosinophils (By similarity). Binds to CCR10 and induces calcium mobilization in a dose- dependent manner. | 0.995 |
Ccl26 | Ccl5 | ENSMUSP00000091779 | ENSMUSP00000039600 | Chemokine (C-C motif) ligand 26. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.997 |
Ccl26 | Ccr10 | ENSMUSP00000091779 | ENSMUSP00000062588 | Chemokine (C-C motif) ligand 26. | C-C chemokine receptor type 10; Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level. | 0.747 |
Ccl26 | Cxcl10 | ENSMUSP00000091779 | ENSMUSP00000047646 | Chemokine (C-C motif) ligand 26. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C- dependent pathway, an increa [...] | 0.984 |
Ccl26 | Cxcl12 | ENSMUSP00000091779 | ENSMUSP00000072800 | Chemokine (C-C motif) ligand 26. | Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (By similarity). Acts as a positive regulator of monocyte migrat [...] | 0.966 |
Ccl26 | Cxcl17 | ENSMUSP00000091779 | ENSMUSP00000144096 | Chemokine (C-C motif) ligand 26. | C-X-C motif chemokine 17; Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C- X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions; Belongs to the intercrine alpha (chemokine CxC) family. | 0.962 |
Ccl26 | Cxcl9 | ENSMUSP00000091779 | ENSMUSP00000108716 | Chemokine (C-C motif) ligand 26. | C-X-C motif chemokine 9; May be a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. | 0.969 |