node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
1700012P22Rik | Ism1 | ENSMUSP00000030323 | ENSMUSP00000139280 | Uncharacterized protein C1orf158 homolog. | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | 0.519 |
Ackr4 | Ism1 | ENSMUSP00000075507 | ENSMUSP00000139280 | Atypical chemokine receptor 4; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin [...] | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | 0.464 |
Caln1 | Ism1 | ENSMUSP00000083193 | ENSMUSP00000139280 | Calcium-binding protein 8; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning. | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | 0.619 |
Gm28778 | Ism1 | ENSMUSP00000141087 | ENSMUSP00000139280 | Predicted gene 28778. | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | 0.460 |
Gm28778 | Ormdl1 | ENSMUSP00000141087 | ENSMUSP00000027266 | Predicted gene 28778. | ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. | 0.542 |
Gm28778 | Ormdl2 | ENSMUSP00000141087 | ENSMUSP00000026409 | Predicted gene 28778. | ORM1-like protein 2; Negative regulator of sphingolipid synthesis. | 0.543 |
Gm28778 | Ormdl3 | ENSMUSP00000141087 | ENSMUSP00000053056 | Predicted gene 28778. | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). | 0.542 |
Gm28778 | Sptlc1 | ENSMUSP00000141087 | ENSMUSP00000021920 | Predicted gene 28778. | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates. The SPTLC1-SPTLC2-SPTSSB complex displays a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme has the ability to use a broader range of acyl-CoAs (By [...] | 0.871 |
Ism1 | 1700012P22Rik | ENSMUSP00000139280 | ENSMUSP00000030323 | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | Uncharacterized protein C1orf158 homolog. | 0.519 |
Ism1 | Ackr4 | ENSMUSP00000139280 | ENSMUSP00000075507 | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | Atypical chemokine receptor 4; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin [...] | 0.464 |
Ism1 | Caln1 | ENSMUSP00000139280 | ENSMUSP00000083193 | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | Calcium-binding protein 8; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning. | 0.619 |
Ism1 | Gm28778 | ENSMUSP00000139280 | ENSMUSP00000141087 | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | Predicted gene 28778. | 0.460 |
Ism1 | Ormdl1 | ENSMUSP00000139280 | ENSMUSP00000027266 | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. | 0.497 |
Ism1 | Ormdl2 | ENSMUSP00000139280 | ENSMUSP00000026409 | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | ORM1-like protein 2; Negative regulator of sphingolipid synthesis. | 0.497 |
Ism1 | Ormdl3 | ENSMUSP00000139280 | ENSMUSP00000053056 | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). | 0.497 |
Ism1 | Sord | ENSMUSP00000139280 | ENSMUSP00000106180 | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols (By similarity). Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility and protein tyrosine phosphorylation. Has no activity on ethanol. Cannot use N [...] | 0.481 |
Ism1 | Sptlc1 | ENSMUSP00000139280 | ENSMUSP00000021920 | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates. The SPTLC1-SPTLC2-SPTSSB complex displays a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme has the ability to use a broader range of acyl-CoAs (By [...] | 0.743 |
Ism1 | Susd2 | ENSMUSP00000139280 | ENSMUSP00000093197 | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | Sushi domain-containing protein 2; May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity). May play a role in breast tumorigenesis. | 0.535 |
Ormdl1 | Gm28778 | ENSMUSP00000027266 | ENSMUSP00000141087 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. | Predicted gene 28778. | 0.542 |
Ormdl1 | Ism1 | ENSMUSP00000027266 | ENSMUSP00000139280 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. | Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family. | 0.497 |