| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Arrb2 | Gpr176 | ENSMUSP00000104208 | ENSMUSP00000037586 | Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production. | 0.407 |
| Arrb2 | Gpr27 | ENSMUSP00000104208 | ENSMUSP00000098680 | Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity). | 0.487 |
| Arrb2 | Gpr84 | ENSMUSP00000104208 | ENSMUSP00000078753 | Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | G-protein coupled receptor 84; Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system (By similarity). | 0.578 |
| Eif4e3 | Gpr27 | ENSMUSP00000032151 | ENSMUSP00000098680 | Eukaryotic translation initiation factor 4E type 3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity. | Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity). | 0.640 |
| Gpr101 | Gpr150 | ENSMUSP00000058183 | ENSMUSP00000049592 | Probable G-protein coupled receptor 101; Orphan receptor. | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.412 |
| Gpr101 | Gpr162 | ENSMUSP00000058183 | ENSMUSP00000145267 | Probable G-protein coupled receptor 101; Orphan receptor. | Probable G-protein coupled receptor 162; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.514 |
| Gpr101 | Gpr27 | ENSMUSP00000058183 | ENSMUSP00000098680 | Probable G-protein coupled receptor 101; Orphan receptor. | Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity). | 0.466 |
| Gpr15 | Gpr150 | ENSMUSP00000086731 | ENSMUSP00000049592 | G-protein coupled receptor 15; Probable chemokine receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.580 |
| Gpr15 | Gpr176 | ENSMUSP00000086731 | ENSMUSP00000037586 | G-protein coupled receptor 15; Probable chemokine receptor; Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production. | 0.472 |
| Gpr15 | Gpr25 | ENSMUSP00000086731 | ENSMUSP00000083583 | G-protein coupled receptor 15; Probable chemokine receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 25; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.474 |
| Gpr15 | Gpr27 | ENSMUSP00000086731 | ENSMUSP00000098680 | G-protein coupled receptor 15; Probable chemokine receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity). | 0.547 |
| Gpr15 | Gpr45 | ENSMUSP00000086731 | ENSMUSP00000135986 | G-protein coupled receptor 15; Probable chemokine receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function. | 0.601 |
| Gpr15 | Gpr84 | ENSMUSP00000086731 | ENSMUSP00000078753 | G-protein coupled receptor 15; Probable chemokine receptor; Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 84; Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system (By similarity). | 0.473 |
| Gpr150 | Gpr101 | ENSMUSP00000049592 | ENSMUSP00000058183 | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 101; Orphan receptor. | 0.412 |
| Gpr150 | Gpr15 | ENSMUSP00000049592 | ENSMUSP00000086731 | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 15; Probable chemokine receptor; Belongs to the G-protein coupled receptor 1 family. | 0.580 |
| Gpr150 | Gpr162 | ENSMUSP00000049592 | ENSMUSP00000145267 | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 162; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.611 |
| Gpr150 | Gpr176 | ENSMUSP00000049592 | ENSMUSP00000037586 | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production. | 0.607 |
| Gpr150 | Gpr25 | ENSMUSP00000049592 | ENSMUSP00000083583 | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 25; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.605 |
| Gpr150 | Gpr27 | ENSMUSP00000049592 | ENSMUSP00000098680 | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity). | 0.638 |
| Gpr150 | Gpr45 | ENSMUSP00000049592 | ENSMUSP00000135986 | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function. | 0.509 |