node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Btrc | Ccdc142 | ENSMUSP00000070728 | ENSMUSP00000098812 | F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (By similarity). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; [...] | Coiled-coil domain-containing protein 142. | 0.439 |
Ccdc142 | Btrc | ENSMUSP00000098812 | ENSMUSP00000070728 | Coiled-coil domain-containing protein 142. | F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (By similarity). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; [...] | 0.439 |
Ccdc142 | Dqx1 | ENSMUSP00000098812 | ENSMUSP00000076708 | Coiled-coil domain-containing protein 142. | ATP-dependent RNA helicase DQX1. | 0.613 |
Ccdc142 | Eif4a1 | ENSMUSP00000098812 | ENSMUSP00000127034 | Coiled-coil domain-containing protein 142. | Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; Belongs to the DEAD box helicase family. eIF4A subfamily. | 0.527 |
Ccdc142 | Eif4a2 | ENSMUSP00000098812 | ENSMUSP00000110998 | Coiled-coil domain-containing protein 142. | Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; Belongs to the DEAD box helicase family. eIF4A subfamily. | 0.527 |
Ccdc142 | Ino80b | ENSMUSP00000098812 | ENSMUSP00000032109 | Coiled-coil domain-containing protein 142. | INO80 complex subunit B; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. | 0.581 |
Ccdc142 | Lbx2 | ENSMUSP00000098812 | ENSMUSP00000047134 | Coiled-coil domain-containing protein 142. | Transcription factor LBX2; Putative transcription factor. | 0.491 |
Ccdc142 | M1ap | ENSMUSP00000098812 | ENSMUSP00000109613 | Coiled-coil domain-containing protein 142. | Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis. | 0.499 |
Ccdc142 | Mrpl53 | ENSMUSP00000098812 | ENSMUSP00000109571 | Coiled-coil domain-containing protein 142. | 39S ribosomal protein L53, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL53 family. | 0.522 |
Ccdc142 | Pole4 | ENSMUSP00000098812 | ENSMUSP00000093462 | Coiled-coil domain-containing protein 142. | DNA polymerase epsilon subunit 4; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). | 0.449 |
Ccdc142 | Wdr54 | ENSMUSP00000098812 | ENSMUSP00000116608 | Coiled-coil domain-containing protein 142. | WD repeat-containing protein 54; When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. | 0.629 |
Dqx1 | Ccdc142 | ENSMUSP00000076708 | ENSMUSP00000098812 | ATP-dependent RNA helicase DQX1. | Coiled-coil domain-containing protein 142. | 0.613 |
Dqx1 | Ino80b | ENSMUSP00000076708 | ENSMUSP00000032109 | ATP-dependent RNA helicase DQX1. | INO80 complex subunit B; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. | 0.642 |
Dqx1 | M1ap | ENSMUSP00000076708 | ENSMUSP00000109613 | ATP-dependent RNA helicase DQX1. | Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis. | 0.402 |
Dqx1 | Mrpl53 | ENSMUSP00000076708 | ENSMUSP00000109571 | ATP-dependent RNA helicase DQX1. | 39S ribosomal protein L53, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL53 family. | 0.423 |
Dqx1 | Wdr54 | ENSMUSP00000076708 | ENSMUSP00000116608 | ATP-dependent RNA helicase DQX1. | WD repeat-containing protein 54; When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. | 0.514 |
Eif4a1 | Ccdc142 | ENSMUSP00000127034 | ENSMUSP00000098812 | Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; Belongs to the DEAD box helicase family. eIF4A subfamily. | Coiled-coil domain-containing protein 142. | 0.527 |
Eif4a1 | Eif4a2 | ENSMUSP00000127034 | ENSMUSP00000110998 | Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; Belongs to the DEAD box helicase family. eIF4A subfamily. | Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; Belongs to the DEAD box helicase family. eIF4A subfamily. | 0.965 |
Eif4a2 | Ccdc142 | ENSMUSP00000110998 | ENSMUSP00000098812 | Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; Belongs to the DEAD box helicase family. eIF4A subfamily. | Coiled-coil domain-containing protein 142. | 0.527 |
Eif4a2 | Eif4a1 | ENSMUSP00000110998 | ENSMUSP00000127034 | Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; Belongs to the DEAD box helicase family. eIF4A subfamily. | Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; Belongs to the DEAD box helicase family. eIF4A subfamily. | 0.965 |