node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abhd12b | Nhsl2 | ENSMUSP00000134568 | ENSMUSP00000098893 | Abhydrolase domain-containing 12B. | NHS-like protein 2; Belongs to the NHS family. | 0.464 |
Ap1ar | Cmtm4 | ENSMUSP00000059669 | ENSMUSP00000137332 | Adaptor-related protein complex 1-associated regulatory protein. | CKLF-like MARVEL transmembrane domain-containing protein 4; Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD- L1/CD274 from being polyubiquitinated and targeted for degradation. | 0.415 |
Ap1ar | Nhsl2 | ENSMUSP00000059669 | ENSMUSP00000098893 | Adaptor-related protein complex 1-associated regulatory protein. | NHS-like protein 2; Belongs to the NHS family. | 0.513 |
Ap1ar | Polr2m | ENSMUSP00000059669 | ENSMUSP00000034720 | Adaptor-related protein complex 1-associated regulatory protein. | DNA-directed RNA polymerase II subunit GRINL1A; Isoform 1 appears to be stable component of the Pol II(G) complex form of RNA polymerase II. Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in Mediator-dependent regulation of transcription activation. Isoform 1 acts in vitro as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equival [...] | 0.534 |
Cmtm4 | Ap1ar | ENSMUSP00000137332 | ENSMUSP00000059669 | CKLF-like MARVEL transmembrane domain-containing protein 4; Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD- L1/CD274 from being polyubiquitinated and targeted for degradation. | Adaptor-related protein complex 1-associated regulatory protein. | 0.415 |
Cmtm4 | Nhsl2 | ENSMUSP00000137332 | ENSMUSP00000098893 | CKLF-like MARVEL transmembrane domain-containing protein 4; Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD- L1/CD274 from being polyubiquitinated and targeted for degradation. | NHS-like protein 2; Belongs to the NHS family. | 0.429 |
Cmtm4 | Polr2m | ENSMUSP00000137332 | ENSMUSP00000034720 | CKLF-like MARVEL transmembrane domain-containing protein 4; Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD- L1/CD274 from being polyubiquitinated and targeted for degradation. | DNA-directed RNA polymerase II subunit GRINL1A; Isoform 1 appears to be stable component of the Pol II(G) complex form of RNA polymerase II. Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in Mediator-dependent regulation of transcription activation. Isoform 1 acts in vitro as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equival [...] | 0.520 |
Commd6 | Nhsl2 | ENSMUSP00000097912 | ENSMUSP00000098893 | COMM domain-containing protein 6; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Inhibits TNF-induced NFKB1 activation. | NHS-like protein 2; Belongs to the NHS family. | 0.425 |
Mmrn2 | Nhsl2 | ENSMUSP00000107539 | ENSMUSP00000098893 | Multimerin-2; Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA. | NHS-like protein 2; Belongs to the NHS family. | 0.424 |
Nckap1 | Nhsl2 | ENSMUSP00000107390 | ENSMUSP00000098893 | Nck-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes ; Belongs to the HEM-1/HEM-2 family. | NHS-like protein 2; Belongs to the NHS family. | 0.484 |
Nckap1 | Wasf2 | ENSMUSP00000107390 | ENSMUSP00000081263 | Nck-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes ; Belongs to the HEM-1/HEM-2 family. | Wiskott-Aldrich syndrome protein family member 2; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). | 0.997 |
Nhsl2 | Abhd12b | ENSMUSP00000098893 | ENSMUSP00000134568 | NHS-like protein 2; Belongs to the NHS family. | Abhydrolase domain-containing 12B. | 0.464 |
Nhsl2 | Ap1ar | ENSMUSP00000098893 | ENSMUSP00000059669 | NHS-like protein 2; Belongs to the NHS family. | Adaptor-related protein complex 1-associated regulatory protein. | 0.513 |
Nhsl2 | Cmtm4 | ENSMUSP00000098893 | ENSMUSP00000137332 | NHS-like protein 2; Belongs to the NHS family. | CKLF-like MARVEL transmembrane domain-containing protein 4; Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD- L1/CD274 from being polyubiquitinated and targeted for degradation. | 0.429 |
Nhsl2 | Commd6 | ENSMUSP00000098893 | ENSMUSP00000097912 | NHS-like protein 2; Belongs to the NHS family. | COMM domain-containing protein 6; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Inhibits TNF-induced NFKB1 activation. | 0.425 |
Nhsl2 | Mmrn2 | ENSMUSP00000098893 | ENSMUSP00000107539 | NHS-like protein 2; Belongs to the NHS family. | Multimerin-2; Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA. | 0.424 |
Nhsl2 | Nckap1 | ENSMUSP00000098893 | ENSMUSP00000107390 | NHS-like protein 2; Belongs to the NHS family. | Nck-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes ; Belongs to the HEM-1/HEM-2 family. | 0.484 |
Nhsl2 | Polr2m | ENSMUSP00000098893 | ENSMUSP00000034720 | NHS-like protein 2; Belongs to the NHS family. | DNA-directed RNA polymerase II subunit GRINL1A; Isoform 1 appears to be stable component of the Pol II(G) complex form of RNA polymerase II. Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in Mediator-dependent regulation of transcription activation. Isoform 1 acts in vitro as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equival [...] | 0.601 |
Nhsl2 | Rtp1 | ENSMUSP00000098893 | ENSMUSP00000043416 | NHS-like protein 2; Belongs to the NHS family. | Receptor-transporting protein 1; Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs. Belongs to the TMEM7 family. | 0.431 |
Nhsl2 | Samd10 | ENSMUSP00000098893 | ENSMUSP00000060499 | NHS-like protein 2; Belongs to the NHS family. | Sterile alpha motif domain-containing protein 10. | 0.479 |