| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Flg | Ivl | ENSMUSP00000142003 | ENSMUSP00000059780 | Filaggrin. | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | 0.873 |
| Flg | Krt1 | ENSMUSP00000142003 | ENSMUSP00000023790 | Filaggrin. | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity); Belongs to the intermediate filament family. | 0.857 |
| Flg | Krt10 | ENSMUSP00000142003 | ENSMUSP00000099420 | Filaggrin. | Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Belongs to the intermediate filament family. | 0.877 |
| Flg | Krt14 | ENSMUSP00000142003 | ENSMUSP00000007272 | Filaggrin. | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. | 0.739 |
| Flg | Krt16 | ENSMUSP00000142003 | ENSMUSP00000007280 | Filaggrin. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. | 0.706 |
| Flg | Krt2 | ENSMUSP00000142003 | ENSMUSP00000023712 | Filaggrin. | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification (By similarity). Associated with keratinocyte activation, proliferation and keratinization (By similarity). Plays a role in the establishment of the epidermal barrier on plantar skin. | 0.593 |
| Flg | Krt5 | ENSMUSP00000142003 | ENSMUSP00000023709 | Filaggrin. | Keratin, type II cytoskeletal 5. | 0.707 |
| Flg | Lor | ENSMUSP00000142003 | ENSMUSP00000052128 | Filaggrin. | Loricrin; Major keratinocyte cell envelope protein. | 0.956 |
| Ivl | Flg | ENSMUSP00000059780 | ENSMUSP00000142003 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | Filaggrin. | 0.873 |
| Ivl | Krt1 | ENSMUSP00000059780 | ENSMUSP00000023790 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity); Belongs to the intermediate filament family. | 0.735 |
| Ivl | Krt10 | ENSMUSP00000059780 | ENSMUSP00000099420 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Belongs to the intermediate filament family. | 0.810 |
| Ivl | Krt14 | ENSMUSP00000059780 | ENSMUSP00000007272 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. | 0.725 |
| Ivl | Krt16 | ENSMUSP00000059780 | ENSMUSP00000007280 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. | 0.507 |
| Ivl | Krt5 | ENSMUSP00000059780 | ENSMUSP00000023709 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | Keratin, type II cytoskeletal 5. | 0.639 |
| Ivl | Lor | ENSMUSP00000059780 | ENSMUSP00000052128 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | Loricrin; Major keratinocyte cell envelope protein. | 0.886 |
| Krt1 | Flg | ENSMUSP00000023790 | ENSMUSP00000142003 | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity); Belongs to the intermediate filament family. | Filaggrin. | 0.857 |
| Krt1 | Ivl | ENSMUSP00000023790 | ENSMUSP00000059780 | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity); Belongs to the intermediate filament family. | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | 0.735 |
| Krt1 | Krt10 | ENSMUSP00000023790 | ENSMUSP00000099420 | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity); Belongs to the intermediate filament family. | Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Belongs to the intermediate filament family. | 0.925 |
| Krt1 | Krt14 | ENSMUSP00000023790 | ENSMUSP00000007272 | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity); Belongs to the intermediate filament family. | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. | 0.517 |
| Krt1 | Krt16 | ENSMUSP00000023790 | ENSMUSP00000007280 | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity); Belongs to the intermediate filament family. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. | 0.475 |
