node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dsg1a | Flg | ENSMUSP00000076393 | ENSMUSP00000142003 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Filaggrin. | 0.798 |
Dsg1a | Hrnr | ENSMUSP00000076393 | ENSMUSP00000088369 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Hornerin; Component of the epidermal cornified cell envelopes; Belongs to the S100-fused protein family. | 0.603 |
Dsg1a | Ivl | ENSMUSP00000076393 | ENSMUSP00000059780 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | 0.630 |
Dsg1a | Krt1 | ENSMUSP00000076393 | ENSMUSP00000023790 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity); Belongs to the intermediate filament family. | 0.813 |
Dsg1a | Krt10 | ENSMUSP00000076393 | ENSMUSP00000099420 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Belongs to the intermediate filament family. | 0.670 |
Dsg1a | Krt2 | ENSMUSP00000076393 | ENSMUSP00000023712 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification (By similarity). Associated with keratinocyte activation, proliferation and keratinization (By similarity). Plays a role in the establishment of the epidermal barrier on plantar skin. | 0.401 |
Dsg1a | Krtdap | ENSMUSP00000076393 | ENSMUSP00000096159 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity). | 0.531 |
Dsg1a | Lor | ENSMUSP00000076393 | ENSMUSP00000052128 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Loricrin; Major keratinocyte cell envelope protein. | 0.703 |
Dsg1a | Tgm1 | ENSMUSP00000076393 | ENSMUSP00000128090 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity). | 0.623 |
Flg | Dsg1a | ENSMUSP00000142003 | ENSMUSP00000076393 | Filaggrin. | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.798 |
Flg | Hrnr | ENSMUSP00000142003 | ENSMUSP00000088369 | Filaggrin. | Hornerin; Component of the epidermal cornified cell envelopes; Belongs to the S100-fused protein family. | 0.738 |
Flg | Ivl | ENSMUSP00000142003 | ENSMUSP00000059780 | Filaggrin. | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | 0.910 |
Flg | Krt1 | ENSMUSP00000142003 | ENSMUSP00000023790 | Filaggrin. | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity); Belongs to the intermediate filament family. | 0.921 |
Flg | Krt10 | ENSMUSP00000142003 | ENSMUSP00000099420 | Filaggrin. | Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Belongs to the intermediate filament family. | 0.935 |
Flg | Krt2 | ENSMUSP00000142003 | ENSMUSP00000023712 | Filaggrin. | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification (By similarity). Associated with keratinocyte activation, proliferation and keratinization (By similarity). Plays a role in the establishment of the epidermal barrier on plantar skin. | 0.630 |
Flg | Krtdap | ENSMUSP00000142003 | ENSMUSP00000096159 | Filaggrin. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity). | 0.523 |
Flg | Lor | ENSMUSP00000142003 | ENSMUSP00000052128 | Filaggrin. | Loricrin; Major keratinocyte cell envelope protein. | 0.996 |
Flg | Tgm1 | ENSMUSP00000142003 | ENSMUSP00000128090 | Filaggrin. | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity). | 0.795 |
Hrnr | Dsg1a | ENSMUSP00000088369 | ENSMUSP00000076393 | Hornerin; Component of the epidermal cornified cell envelopes; Belongs to the S100-fused protein family. | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.603 |
Hrnr | Flg | ENSMUSP00000088369 | ENSMUSP00000142003 | Hornerin; Component of the epidermal cornified cell envelopes; Belongs to the S100-fused protein family. | Filaggrin. | 0.738 |