node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
2510039O18Rik | Asna1 | ENSMUSP00000099522 | ENSMUSP00000065337 | Uncharacterized protein KIAA2013. | ATPase Asna1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.607 |
2510039O18Rik | Axin1 | ENSMUSP00000099522 | ENSMUSP00000073974 | Uncharacterized protein KIAA2013. | Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upo [...] | 0.567 |
2510039O18Rik | Esyt2 | ENSMUSP00000099522 | ENSMUSP00000098548 | Uncharacterized protein KIAA2013. | Extended synaptotagmin-2; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP- 2 complex (By similarity). | 0.542 |
2510039O18Rik | Hectd3 | ENSMUSP00000099522 | ENSMUSP00000051922 | Uncharacterized protein KIAA2013. | E3 ubiquitin-protein ligase HECTD3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP (By similarity). Mediates also ubiquitination of STX8. | 0.591 |
2510039O18Rik | Lemd2 | ENSMUSP00000099522 | ENSMUSP00000058221 | Uncharacterized protein KIAA2013. | LEM domain-containing protein 2; Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope (By similarity). | 0.567 |
2510039O18Rik | Mblac2 | ENSMUSP00000099522 | ENSMUSP00000051644 | Uncharacterized protein KIAA2013. | Metallo-beta-lactamase domain-containing protein 2. | 0.674 |
2510039O18Rik | Otud4 | ENSMUSP00000099522 | ENSMUSP00000133939 | Uncharacterized protein KIAA2013. | OTU domain-containing protein 4; Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'- polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic a [...] | 0.603 |
2510039O18Rik | Plod1 | ENSMUSP00000099522 | ENSMUSP00000019199 | Uncharacterized protein KIAA2013. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. | 0.573 |
2510039O18Rik | Vac14 | ENSMUSP00000099522 | ENSMUSP00000034190 | Uncharacterized protein KIAA2013. | Protein VAC14 homolog; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. | 0.564 |
2510039O18Rik | Vps13d | ENSMUSP00000099522 | ENSMUSP00000043240 | Uncharacterized protein KIAA2013. | Vacuolar protein sorting 13D. | 0.646 |
Asna1 | 2510039O18Rik | ENSMUSP00000065337 | ENSMUSP00000099522 | ATPase Asna1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Uncharacterized protein KIAA2013. | 0.607 |
Axin1 | 2510039O18Rik | ENSMUSP00000073974 | ENSMUSP00000099522 | Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upo [...] | Uncharacterized protein KIAA2013. | 0.567 |
Esyt2 | 2510039O18Rik | ENSMUSP00000098548 | ENSMUSP00000099522 | Extended synaptotagmin-2; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP- 2 complex (By similarity). | Uncharacterized protein KIAA2013. | 0.542 |
Esyt2 | Mblac2 | ENSMUSP00000098548 | ENSMUSP00000051644 | Extended synaptotagmin-2; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP- 2 complex (By similarity). | Metallo-beta-lactamase domain-containing protein 2. | 0.613 |
Hectd3 | 2510039O18Rik | ENSMUSP00000051922 | ENSMUSP00000099522 | E3 ubiquitin-protein ligase HECTD3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP (By similarity). Mediates also ubiquitination of STX8. | Uncharacterized protein KIAA2013. | 0.591 |
Lemd2 | 2510039O18Rik | ENSMUSP00000058221 | ENSMUSP00000099522 | LEM domain-containing protein 2; Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope (By similarity). | Uncharacterized protein KIAA2013. | 0.567 |
Mblac2 | 2510039O18Rik | ENSMUSP00000051644 | ENSMUSP00000099522 | Metallo-beta-lactamase domain-containing protein 2. | Uncharacterized protein KIAA2013. | 0.674 |
Mblac2 | Esyt2 | ENSMUSP00000051644 | ENSMUSP00000098548 | Metallo-beta-lactamase domain-containing protein 2. | Extended synaptotagmin-2; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP- 2 complex (By similarity). | 0.613 |
Otud4 | 2510039O18Rik | ENSMUSP00000133939 | ENSMUSP00000099522 | OTU domain-containing protein 4; Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'- polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic a [...] | Uncharacterized protein KIAA2013. | 0.603 |
Plod1 | 2510039O18Rik | ENSMUSP00000019199 | ENSMUSP00000099522 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. | Uncharacterized protein KIAA2013. | 0.573 |