| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Mybpc3 | Myh3 | ENSMUSP00000127070 | ENSMUSP00000104329 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | Myosin-3; Muscle contraction. | 0.800 |
| Mybpc3 | Myh7 | ENSMUSP00000127070 | ENSMUSP00000126840 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.988 |
| Mybpc3 | Myl1 | ENSMUSP00000127070 | ENSMUSP00000027151 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.737 |
| Mybpc3 | Myl2 | ENSMUSP00000127070 | ENSMUSP00000107380 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites t [...] | 0.986 |
| Mybpc3 | Myl3 | ENSMUSP00000127070 | ENSMUSP00000078715 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.990 |
| Mybpc3 | Myl4 | ENSMUSP00000127070 | ENSMUSP00000102570 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium. | 0.835 |
| Mybpc3 | Myl6 | ENSMUSP00000127070 | ENSMUSP00000128803 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium. | 0.443 |
| Mybpc3 | Myl9 | ENSMUSP00000127070 | ENSMUSP00000085913 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. | 0.459 |
| Mybpc3 | Ttn | ENSMUSP00000127070 | ENSMUSP00000107477 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. | 0.898 |
| Myh3 | Mybpc3 | ENSMUSP00000104329 | ENSMUSP00000127070 | Myosin-3; Muscle contraction. | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | 0.800 |
| Myh3 | Myh7 | ENSMUSP00000104329 | ENSMUSP00000126840 | Myosin-3; Muscle contraction. | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.962 |
| Myh3 | Myl1 | ENSMUSP00000104329 | ENSMUSP00000027151 | Myosin-3; Muscle contraction. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.983 |
| Myh3 | Myl2 | ENSMUSP00000104329 | ENSMUSP00000107380 | Myosin-3; Muscle contraction. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites t [...] | 0.901 |
| Myh3 | Myl3 | ENSMUSP00000104329 | ENSMUSP00000078715 | Myosin-3; Muscle contraction. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.975 |
| Myh3 | Myl4 | ENSMUSP00000104329 | ENSMUSP00000102570 | Myosin-3; Muscle contraction. | Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium. | 0.984 |
| Myh3 | Myl6 | ENSMUSP00000104329 | ENSMUSP00000128803 | Myosin-3; Muscle contraction. | Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium. | 0.958 |
| Myh3 | Myl6b | ENSMUSP00000104329 | ENSMUSP00000026428 | Myosin-3; Muscle contraction. | Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium. | 0.968 |
| Myh3 | Myl9 | ENSMUSP00000104329 | ENSMUSP00000085913 | Myosin-3; Muscle contraction. | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. | 0.949 |
| Myh3 | Ttn | ENSMUSP00000104329 | ENSMUSP00000107477 | Myosin-3; Muscle contraction. | Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. | 0.969 |
| Myh7 | Mybpc3 | ENSMUSP00000126840 | ENSMUSP00000127070 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | 0.988 |
