node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc186 | Eipr1 | ENSMUSP00000113457 | ENSMUSP00000152220 | Coiled-coil domain-containing protein 186. | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | 0.788 |
Ccdc186 | Hid1 | ENSMUSP00000113457 | ENSMUSP00000102152 | Coiled-coil domain-containing protein 186. | Protein HID1; Belongs to the hid-1 family. | 0.583 |
Eipr1 | Ccdc186 | ENSMUSP00000152220 | ENSMUSP00000113457 | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | Coiled-coil domain-containing protein 186. | 0.788 |
Eipr1 | Hid1 | ENSMUSP00000152220 | ENSMUSP00000102152 | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | Protein HID1; Belongs to the hid-1 family. | 0.647 |
Eipr1 | Vps41 | ENSMUSP00000152220 | ENSMUSP00000072729 | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal me [...] | 0.544 |
Gle1 | Hid1 | ENSMUSP00000019859 | ENSMUSP00000102152 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). | Protein HID1; Belongs to the hid-1 family. | 0.611 |
Gle1 | Nup155 | ENSMUSP00000019859 | ENSMUSP00000128819 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. Belongs to the non-repetitive/WGA-negative nucleoporin family. | 0.975 |
Gle1 | Nup214 | ENSMUSP00000019859 | ENSMUSP00000066492 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). | Nuclear pore complex protein Nup214; Has a critical role in nucleocytoplasmic transport (By similarity). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. | 0.995 |
Gle1 | Nup54 | ENSMUSP00000019859 | ENSMUSP00000046540 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). | Nuclear pore complex protein Nup54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | 0.939 |
Hid1 | Ccdc186 | ENSMUSP00000102152 | ENSMUSP00000113457 | Protein HID1; Belongs to the hid-1 family. | Coiled-coil domain-containing protein 186. | 0.583 |
Hid1 | Eipr1 | ENSMUSP00000102152 | ENSMUSP00000152220 | Protein HID1; Belongs to the hid-1 family. | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | 0.647 |
Hid1 | Gle1 | ENSMUSP00000102152 | ENSMUSP00000019859 | Protein HID1; Belongs to the hid-1 family. | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). | 0.611 |
Hid1 | Nup155 | ENSMUSP00000102152 | ENSMUSP00000128819 | Protein HID1; Belongs to the hid-1 family. | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. Belongs to the non-repetitive/WGA-negative nucleoporin family. | 0.596 |
Hid1 | Nup214 | ENSMUSP00000102152 | ENSMUSP00000066492 | Protein HID1; Belongs to the hid-1 family. | Nuclear pore complex protein Nup214; Has a critical role in nucleocytoplasmic transport (By similarity). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. | 0.506 |
Hid1 | Nup54 | ENSMUSP00000102152 | ENSMUSP00000046540 | Protein HID1; Belongs to the hid-1 family. | Nuclear pore complex protein Nup54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | 0.524 |
Hid1 | Otop2 | ENSMUSP00000102152 | ENSMUSP00000062109 | Protein HID1; Belongs to the hid-1 family. | Proton channel OTOP2; Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. | 0.487 |
Hid1 | Usp40 | ENSMUSP00000102152 | ENSMUSP00000140107 | Protein HID1; Belongs to the hid-1 family. | Ubiquitin carboxyl-terminal hydrolase 40; Belongs to the peptidase C19 family. | 0.650 |
Hid1 | Usp7 | ENSMUSP00000102152 | ENSMUSP00000124093 | Protein HID1; Belongs to the hid-1 family. | Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presen [...] | 0.650 |
Hid1 | Vps41 | ENSMUSP00000102152 | ENSMUSP00000072729 | Protein HID1; Belongs to the hid-1 family. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal me [...] | 0.667 |
Nup155 | Gle1 | ENSMUSP00000128819 | ENSMUSP00000019859 | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. Belongs to the non-repetitive/WGA-negative nucleoporin family. | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). | 0.975 |