node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acox2 | Acp4 | ENSMUSP00000126464 | ENSMUSP00000112922 | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (By similarity). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis; Belongs to the histidine acid phosphatase family. | 0.525 |
Acox2 | Amtn | ENSMUSP00000126464 | ENSMUSP00000073081 | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (By similarity). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. Belongs to the amelotin family. | 0.435 |
Acp4 | Acox2 | ENSMUSP00000112922 | ENSMUSP00000126464 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis; Belongs to the histidine acid phosphatase family. | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (By similarity). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). | 0.525 |
Acp4 | Ambn | ENSMUSP00000112922 | ENSMUSP00000142944 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis; Belongs to the histidine acid phosphatase family. | Ameloblastin; Involved in the mineralization and structural organization of enamel. | 0.617 |
Acp4 | Amelx | ENSMUSP00000112922 | ENSMUSP00000065966 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis; Belongs to the histidine acid phosphatase family. | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | 0.599 |
Acp4 | Amtn | ENSMUSP00000112922 | ENSMUSP00000073081 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis; Belongs to the histidine acid phosphatase family. | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. Belongs to the amelotin family. | 0.683 |
Acp4 | Enam | ENSMUSP00000112922 | ENSMUSP00000031222 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis; Belongs to the histidine acid phosphatase family. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.746 |
Acp4 | Fam20a | ENSMUSP00000112922 | ENSMUSP00000020938 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis; Belongs to the histidine acid phosphatase family. | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | 0.619 |
Acp4 | Klk4 | ENSMUSP00000112922 | ENSMUSP00000007161 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis; Belongs to the histidine acid phosphatase family. | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix. | 0.545 |
Acp4 | Odam | ENSMUSP00000112922 | ENSMUSP00000117898 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis; Belongs to the histidine acid phosphatase family. | Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. | 0.578 |
Acp4 | Odaph | ENSMUSP00000112922 | ENSMUSP00000136951 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis; Belongs to the histidine acid phosphatase family. | Odontogenesis-associated phosphoprotein. | 0.541 |
Acp4 | Wdr72 | ENSMUSP00000112922 | ENSMUSP00000057320 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis; Belongs to the histidine acid phosphatase family. | WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. | 0.549 |
Ambn | Acp4 | ENSMUSP00000142944 | ENSMUSP00000112922 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis; Belongs to the histidine acid phosphatase family. | 0.617 |
Ambn | Amelx | ENSMUSP00000142944 | ENSMUSP00000065966 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | 0.992 |
Ambn | Amtn | ENSMUSP00000142944 | ENSMUSP00000073081 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. Belongs to the amelotin family. | 0.961 |
Ambn | Enam | ENSMUSP00000142944 | ENSMUSP00000031222 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.991 |
Ambn | Fam20a | ENSMUSP00000142944 | ENSMUSP00000020938 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | 0.794 |
Ambn | Klk4 | ENSMUSP00000142944 | ENSMUSP00000007161 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix. | 0.874 |
Ambn | Odam | ENSMUSP00000142944 | ENSMUSP00000117898 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. | 0.752 |
Ambn | Odaph | ENSMUSP00000142944 | ENSMUSP00000136951 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Odontogenesis-associated phosphoprotein. | 0.535 |