node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arfrp1 | Cog6 | ENSMUSP00000122066 | ENSMUSP00000048603 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | 0.735 |
Arfrp1 | Cog8 | ENSMUSP00000122066 | ENSMUSP00000093173 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.880 |
Arfrp1 | Golga1 | ENSMUSP00000122066 | ENSMUSP00000037735 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | Golgin subfamily A member 1; Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. | 0.744 |
Arfrp1 | Rab6a | ENSMUSP00000122066 | ENSMUSP00000032946 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | Ras-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.757 |
Arfrp1 | Rab6b | ENSMUSP00000122066 | ENSMUSP00000035155 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | Ras-related protein Rab-6B; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.731 |
Arfrp1 | Ric1 | ENSMUSP00000122066 | ENSMUSP00000043437 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.782 |
Arfrp1 | Sys1 | ENSMUSP00000122066 | ENSMUSP00000104976 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1 (By similarity). | 0.935 |
Arfrp1 | Vps52 | ENSMUSP00000122066 | ENSMUSP00000025178 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] | 0.756 |
Arfrp1 | Vps53 | ENSMUSP00000122066 | ENSMUSP00000061317 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] | 0.730 |
Arfrp1 | Vps54 | ENSMUSP00000122066 | ENSMUSP00000006221 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling. | 0.690 |
Cog6 | Arfrp1 | ENSMUSP00000048603 | ENSMUSP00000122066 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | 0.735 |
Cog6 | Cog8 | ENSMUSP00000048603 | ENSMUSP00000093173 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.999 |
Cog6 | Golga1 | ENSMUSP00000048603 | ENSMUSP00000037735 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Golgin subfamily A member 1; Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. | 0.714 |
Cog6 | Rab6a | ENSMUSP00000048603 | ENSMUSP00000032946 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Ras-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.781 |
Cog6 | Rab6b | ENSMUSP00000048603 | ENSMUSP00000035155 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Ras-related protein Rab-6B; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.719 |
Cog6 | Ric1 | ENSMUSP00000048603 | ENSMUSP00000043437 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.699 |
Cog6 | Sys1 | ENSMUSP00000048603 | ENSMUSP00000104976 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1 (By similarity). | 0.619 |
Cog6 | Vps52 | ENSMUSP00000048603 | ENSMUSP00000025178 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] | 0.877 |
Cog6 | Vps53 | ENSMUSP00000048603 | ENSMUSP00000061317 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] | 0.906 |
Cog6 | Vps54 | ENSMUSP00000048603 | ENSMUSP00000006221 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling. | 0.863 |