node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Astn2 | Phactr3 | ENSMUSP00000065786 | ENSMUSP00000104543 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1. Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (By similarity). | Phosphatase and actin regulator 3. | 0.478 |
Cacna1i | Phactr3 | ENSMUSP00000125063 | ENSMUSP00000104543 | Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] | Phosphatase and actin regulator 3. | 0.502 |
Dpysl4 | Phactr3 | ENSMUSP00000026551 | ENSMUSP00000104543 | Dihydropyrimidinase-related protein 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | Phosphatase and actin regulator 3. | 0.507 |
Pfdn4 | Phactr3 | ENSMUSP00000070596 | ENSMUSP00000104543 | Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family. | Phosphatase and actin regulator 3. | 0.481 |
Phactr3 | Astn2 | ENSMUSP00000104543 | ENSMUSP00000065786 | Phosphatase and actin regulator 3. | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1. Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (By similarity). | 0.478 |
Phactr3 | Cacna1i | ENSMUSP00000104543 | ENSMUSP00000125063 | Phosphatase and actin regulator 3. | Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] | 0.502 |
Phactr3 | Dpysl4 | ENSMUSP00000104543 | ENSMUSP00000026551 | Phosphatase and actin regulator 3. | Dihydropyrimidinase-related protein 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | 0.507 |
Phactr3 | Pfdn4 | ENSMUSP00000104543 | ENSMUSP00000070596 | Phosphatase and actin regulator 3. | Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family. | 0.481 |
Phactr3 | Phyhipl | ENSMUSP00000104543 | ENSMUSP00000045807 | Phosphatase and actin regulator 3. | Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system. Belongs to the PHYHIP family. | 0.595 |
Phactr3 | Smim17 | ENSMUSP00000104543 | ENSMUSP00000126877 | Phosphatase and actin regulator 3. | Small integral membrane protein 17. | 0.659 |
Phactr3 | Tafa4 | ENSMUSP00000104543 | ENSMUSP00000086710 | Phosphatase and actin regulator 3. | Chemokine-like protein TAFA-4; Modulates injury-induced and chemical pain hypersensitivity. Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release. | 0.564 |
Phactr3 | Tma16 | ENSMUSP00000104543 | ENSMUSP00000026681 | Phosphatase and actin regulator 3. | Translation machinery-associated protein 16. | 0.677 |
Phactr3 | Tmem214 | ENSMUSP00000104543 | ENSMUSP00000144615 | Phosphatase and actin regulator 3. | Transmembrane protein 214; Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress (By similarity); Belongs to the TMEM214 family. | 0.459 |
Phactr3 | Zfp931 | ENSMUSP00000104543 | ENSMUSP00000104552 | Phosphatase and actin regulator 3. | Zinc finger protein 931. | 0.491 |
Phyhipl | Phactr3 | ENSMUSP00000045807 | ENSMUSP00000104543 | Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system. Belongs to the PHYHIP family. | Phosphatase and actin regulator 3. | 0.595 |
Phyhipl | Tma16 | ENSMUSP00000045807 | ENSMUSP00000026681 | Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system. Belongs to the PHYHIP family. | Translation machinery-associated protein 16. | 0.662 |
Smim17 | Phactr3 | ENSMUSP00000126877 | ENSMUSP00000104543 | Small integral membrane protein 17. | Phosphatase and actin regulator 3. | 0.659 |
Smim17 | Tmem214 | ENSMUSP00000126877 | ENSMUSP00000144615 | Small integral membrane protein 17. | Transmembrane protein 214; Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress (By similarity); Belongs to the TMEM214 family. | 0.645 |
Tafa4 | Phactr3 | ENSMUSP00000086710 | ENSMUSP00000104543 | Chemokine-like protein TAFA-4; Modulates injury-induced and chemical pain hypersensitivity. Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release. | Phosphatase and actin regulator 3. | 0.564 |
Tma16 | Phactr3 | ENSMUSP00000026681 | ENSMUSP00000104543 | Translation machinery-associated protein 16. | Phosphatase and actin regulator 3. | 0.677 |