node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atp13a3 | Zfp354a | ENSMUSP00000128224 | ENSMUSP00000104747 | Probable cation-transporting ATPase 13A3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | 0.436 |
Lin54 | Usp50 | ENSMUSP00000123425 | ENSMUSP00000028842 | Protein lin-54 homolog; Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensu [...] | Putative ubiquitin carboxyl-terminal hydrolase 50; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Belongs to the peptidase C19 family. | 0.593 |
Lin54 | Zfp354a | ENSMUSP00000123425 | ENSMUSP00000104747 | Protein lin-54 homolog; Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensu [...] | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | 0.566 |
Rec114 | Zfp354a | ENSMUSP00000096271 | ENSMUSP00000104747 | Meiotic recombination protein REC114; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | 0.474 |
Sry | Zfp354a | ENSMUSP00000088717 | ENSMUSP00000104747 | Sex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bend [...] | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | 0.506 |
Trim28 | Zfp354a | ENSMUSP00000005705 | ENSMUSP00000104747 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | 0.653 |
Tusc1 | Zfp354a | ENSMUSP00000069652 | ENSMUSP00000104747 | Tumor suppressor candidate gene 1 protein homolog. | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | 0.400 |
Usp50 | Lin54 | ENSMUSP00000028842 | ENSMUSP00000123425 | Putative ubiquitin carboxyl-terminal hydrolase 50; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Belongs to the peptidase C19 family. | Protein lin-54 homolog; Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensu [...] | 0.593 |
Usp50 | Zfp354a | ENSMUSP00000028842 | ENSMUSP00000104747 | Putative ubiquitin carboxyl-terminal hydrolase 50; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Belongs to the peptidase C19 family. | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | 0.661 |
Zfp354a | Atp13a3 | ENSMUSP00000104747 | ENSMUSP00000128224 | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | Probable cation-transporting ATPase 13A3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.436 |
Zfp354a | Lin54 | ENSMUSP00000104747 | ENSMUSP00000123425 | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | Protein lin-54 homolog; Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensu [...] | 0.566 |
Zfp354a | Rec114 | ENSMUSP00000104747 | ENSMUSP00000096271 | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | Meiotic recombination protein REC114; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. | 0.474 |
Zfp354a | Sry | ENSMUSP00000104747 | ENSMUSP00000088717 | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | Sex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bend [...] | 0.506 |
Zfp354a | Trim28 | ENSMUSP00000104747 | ENSMUSP00000005705 | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.653 |
Zfp354a | Tusc1 | ENSMUSP00000104747 | ENSMUSP00000069652 | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | Tumor suppressor candidate gene 1 protein homolog. | 0.400 |
Zfp354a | Usp50 | ENSMUSP00000104747 | ENSMUSP00000028842 | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | Putative ubiquitin carboxyl-terminal hydrolase 50; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Belongs to the peptidase C19 family. | 0.661 |
Zfp354a | Zfp608 | ENSMUSP00000104747 | ENSMUSP00000068192 | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription. | 0.425 |
Zfp608 | Zfp354a | ENSMUSP00000068192 | ENSMUSP00000104747 | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription. | Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration. | 0.425 |