Ildr2 protein (mouse) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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co-expression

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gene neighborhood

gene co-occurrence

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Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Arhgap5	Ildr2	ENSMUSP00000151809	ENSMUSP00000107047	Rho GTPase-activating protein 5; GTPase-activating protein for Rho family members.	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	0.488
Igsf21	Ildr2	ENSMUSP00000046558	ENSMUSP00000107047	Immunoglobulin superfamily member 21; Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2.	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	0.488
Igsf21	Srcin1	ENSMUSP00000046558	ENSMUSP00000103222	Immunoglobulin superfamily member 21; Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2.	SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance (By similarity).	0.638
Ildr2	Arhgap5	ENSMUSP00000107047	ENSMUSP00000151809	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	Rho GTPase-activating protein 5; GTPase-activating protein for Rho family members.	0.488
Ildr2	Igsf21	ENSMUSP00000107047	ENSMUSP00000046558	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	Immunoglobulin superfamily member 21; Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2.	0.488
Ildr2	Marveld2	ENSMUSP00000107047	ENSMUSP00000153294	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	MARVEL domain-containing protein 2; Plays a role in the formation of tricellular tight junctions and of epithelial barriers. Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti.	0.702
Ildr2	Nlrp10	ENSMUSP00000107047	ENSMUSP00000050252	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	NACHT, LRR and PYD domains-containing protein 10; Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (By similarity). Displays anti- inflammatory activity (By similarity). Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (By similarity). Contributes to T-cell-mediated inflammatory responses in the skin. Plays a role in protection against periodonti [...]	0.498
Ildr2	Srcin1	ENSMUSP00000107047	ENSMUSP00000103222	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance (By similarity).	0.610
Ildr2	Tbc1d9	ENSMUSP00000107047	ENSMUSP00000091093	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s).	0.488
Ildr2	Tra2a	ENSMUSP00000107047	ENSMUSP00000031841	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	Transformer-2 protein homolog alpha; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing; Belongs to the splicing factor SR family.	0.498
Ildr2	Wdr59	ENSMUSP00000107047	ENSMUSP00000034437	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	GATOR complex protein WDR59; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. Belongs to the WD repeat WDR59 family.	0.488
Ildr2	Zfp2	ENSMUSP00000107047	ENSMUSP00000112079	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	Zinc finger protein 2; Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.	0.494
Ildr2	Zfp37	ENSMUSP00000107047	ENSMUSP00000070463	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	Zinc finger protein 37; May have a role in regulating spermiogenesis.	0.494
Marveld2	Ildr2	ENSMUSP00000153294	ENSMUSP00000107047	MARVEL domain-containing protein 2; Plays a role in the formation of tricellular tight junctions and of epithelial barriers. Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti.	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	0.702
Nlrp10	Ildr2	ENSMUSP00000050252	ENSMUSP00000107047	NACHT, LRR and PYD domains-containing protein 10; Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (By similarity). Displays anti- inflammatory activity (By similarity). Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (By similarity). Contributes to T-cell-mediated inflammatory responses in the skin. Plays a role in protection against periodonti [...]	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	0.498
Srcin1	Igsf21	ENSMUSP00000103222	ENSMUSP00000046558	SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance (By similarity).	Immunoglobulin superfamily member 21; Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2.	0.638
Srcin1	Ildr2	ENSMUSP00000103222	ENSMUSP00000107047	SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance (By similarity).	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	0.610
Tbc1d9	Ildr2	ENSMUSP00000091093	ENSMUSP00000107047	TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s).	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	0.488
Tra2a	Ildr2	ENSMUSP00000031841	ENSMUSP00000107047	Transformer-2 protein homolog alpha; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing; Belongs to the splicing factor SR family.	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	0.498
Wdr59	Ildr2	ENSMUSP00000034437	ENSMUSP00000107047	GATOR complex protein WDR59; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. Belongs to the WD repeat WDR59 family.	Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways.	0.488