node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Camta1 | Casz1 | ENSMUSP00000054804 | ENSMUSP00000112978 | Calmodulin-binding transcription activator 1; Transcriptional activator; Belongs to the CAMTA family. | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | 0.556 |
Casz1 | Camta1 | ENSMUSP00000112978 | ENSMUSP00000054804 | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | Calmodulin-binding transcription activator 1; Transcriptional activator; Belongs to the CAMTA family. | 0.556 |
Casz1 | Espn | ENSMUSP00000112978 | ENSMUSP00000030785 | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | 0.449 |
Casz1 | Hdac2 | ENSMUSP00000112978 | ENSMUSP00000019911 | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor co [...] | 0.489 |
Casz1 | Ikzf1 | ENSMUSP00000112978 | ENSMUSP00000075992 | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | DNA-binding protein Ikaros; Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single compl [...] | 0.452 |
Casz1 | N4bp1 | ENSMUSP00000112978 | ENSMUSP00000034074 | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | NEDD4-binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates. Belongs to the N4BP1 family. | 0.462 |
Casz1 | Rnf2 | ENSMUSP00000112978 | ENSMUSP00000140896 | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] | 0.461 |
Casz1 | Sh2b3 | ENSMUSP00000112978 | ENSMUSP00000083490 | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | SH2B adapter protein 3; Links T-cell receptor activation signal to phospholipase C- gamma-1, GRB2 and phosphatidylinositol 3-kinase; Belongs to the SH2B adapter family. | 0.498 |
Casz1 | Suz12 | ENSMUSP00000112978 | ENSMUSP00000017692 | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | Polycomb protein Suz12; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED- EZH2 complex include HOXA7, HOXB6 and HOXC8. Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. | 0.518 |
Casz1 | Tbx20 | ENSMUSP00000112978 | ENSMUSP00000052591 | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | T-box transcription factor TBX20; Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart. | 0.535 |
Casz1 | Zfp1 | ENSMUSP00000112978 | ENSMUSP00000076964 | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | Zinc finger protein 1; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.457 |
Espn | Casz1 | ENSMUSP00000030785 | ENSMUSP00000112978 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | 0.449 |
Hdac2 | Casz1 | ENSMUSP00000019911 | ENSMUSP00000112978 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor co [...] | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | 0.489 |
Hdac2 | Ikzf1 | ENSMUSP00000019911 | ENSMUSP00000075992 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor co [...] | DNA-binding protein Ikaros; Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single compl [...] | 0.885 |
Hdac2 | Rnf2 | ENSMUSP00000019911 | ENSMUSP00000140896 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor co [...] | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] | 0.910 |
Hdac2 | Suz12 | ENSMUSP00000019911 | ENSMUSP00000017692 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor co [...] | Polycomb protein Suz12; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED- EZH2 complex include HOXA7, HOXB6 and HOXC8. Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. | 0.970 |
Hdac2 | Tbx20 | ENSMUSP00000019911 | ENSMUSP00000052591 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor co [...] | T-box transcription factor TBX20; Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart. | 0.428 |
Ikzf1 | Casz1 | ENSMUSP00000075992 | ENSMUSP00000112978 | DNA-binding protein Ikaros; Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single compl [...] | Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. | 0.452 |
Ikzf1 | Hdac2 | ENSMUSP00000075992 | ENSMUSP00000019911 | DNA-binding protein Ikaros; Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single compl [...] | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor co [...] | 0.885 |
Ikzf1 | Sh2b3 | ENSMUSP00000075992 | ENSMUSP00000083490 | DNA-binding protein Ikaros; Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single compl [...] | SH2B adapter protein 3; Links T-cell receptor activation signal to phospholipase C- gamma-1, GRB2 and phosphatidylinositol 3-kinase; Belongs to the SH2B adapter family. | 0.536 |