node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bud31 | Cdc40 | ENSMUSP00000125564 | ENSMUSP00000044305 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | 0.996 |
Bud31 | Cwc15 | ENSMUSP00000125564 | ENSMUSP00000004200 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | Spliceosome-associated protein CWC15 homolog; Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing. | 0.997 |
Bud31 | Eftud2 | ENSMUSP00000125564 | ENSMUSP00000021306 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | 116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). | 0.998 |
Bud31 | Isy1 | ENSMUSP00000125564 | ENSMUSP00000086923 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | Pre-mRNA-splicing factor ISY1 homolog; Component of the spliceosome C complex required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively. Required during the transition of embryonic stem cells (ESCs) from the naive to primed state. By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an in [...] | 0.998 |
Bud31 | Prpf8 | ENSMUSP00000125564 | ENSMUSP00000018449 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both t [...] | 0.996 |
Bud31 | Snrnp200 | ENSMUSP00000125564 | ENSMUSP00000099509 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | U5 small nuclear ribonucleoprotein 200 kDa helicase; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. | 0.989 |
Bud31 | Snrpa1 | ENSMUSP00000125564 | ENSMUSP00000117947 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | U2 small nuclear ribonucleoprotein A; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. | 0.996 |
Bud31 | Snw1 | ENSMUSP00000125564 | ENSMUSP00000021428 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | SNW domain-containing protein 1; Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, [...] | 0.998 |
Bud31 | Srrm3 | ENSMUSP00000125564 | ENSMUSP00000115695 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | Serine/arginine repetitive matrix protein 3; May play a role in regulating breast cancer cell invasiveness. May be involved in RYBP-mediated breast cancer progression; Belongs to the CWC21 family. | 0.852 |
Bud31 | Syf2 | ENSMUSP00000125564 | ENSMUSP00000030622 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the SYF2 family. | 0.996 |
Cdc40 | Bud31 | ENSMUSP00000044305 | ENSMUSP00000125564 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | 0.996 |
Cdc40 | Cwc15 | ENSMUSP00000044305 | ENSMUSP00000004200 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Spliceosome-associated protein CWC15 homolog; Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing. | 0.994 |
Cdc40 | Eftud2 | ENSMUSP00000044305 | ENSMUSP00000021306 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | 116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). | 0.997 |
Cdc40 | Isy1 | ENSMUSP00000044305 | ENSMUSP00000086923 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor ISY1 homolog; Component of the spliceosome C complex required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively. Required during the transition of embryonic stem cells (ESCs) from the naive to primed state. By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an in [...] | 0.992 |
Cdc40 | Prpf8 | ENSMUSP00000044305 | ENSMUSP00000018449 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both t [...] | 0.996 |
Cdc40 | Snrnp200 | ENSMUSP00000044305 | ENSMUSP00000099509 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | U5 small nuclear ribonucleoprotein 200 kDa helicase; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. | 0.990 |
Cdc40 | Snrpa1 | ENSMUSP00000044305 | ENSMUSP00000117947 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | U2 small nuclear ribonucleoprotein A; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. | 0.997 |
Cdc40 | Snw1 | ENSMUSP00000044305 | ENSMUSP00000021428 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | SNW domain-containing protein 1; Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, [...] | 0.998 |
Cdc40 | Srrm3 | ENSMUSP00000044305 | ENSMUSP00000115695 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Serine/arginine repetitive matrix protein 3; May play a role in regulating breast cancer cell invasiveness. May be involved in RYBP-mediated breast cancer progression; Belongs to the CWC21 family. | 0.867 |
Cdc40 | Syf2 | ENSMUSP00000044305 | ENSMUSP00000030622 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the SYF2 family. | 0.998 |