node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bid | Mtch2 | ENSMUSP00000004560 | ENSMUSP00000118566 | BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c. | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.665 |
Gnpda2 | Kctd15 | ENSMUSP00000031117 | ENSMUSP00000032709 | Glucosamine-6-phosphate isomerase 2; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity). | 0.793 |
Gnpda2 | Mtch2 | ENSMUSP00000031117 | ENSMUSP00000118566 | Glucosamine-6-phosphate isomerase 2; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.794 |
Gnpda2 | Negr1 | ENSMUSP00000031117 | ENSMUSP00000073664 | Glucosamine-6-phosphate isomerase 2; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. | Neuronal growth regulator 1; May be involved in cell-adhesion. May function as a trans- neural growth-promoting factor in regenerative axon sprouting in the mammalian brain. | 0.811 |
Gnpda2 | Sec16b | ENSMUSP00000031117 | ENSMUSP00000083300 | Glucosamine-6-phosphate isomerase 2; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. | Protein transport protein Sec16B; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes; Belongs to the SEC16 family. | 0.801 |
Gnpda2 | Sh2b1 | ENSMUSP00000031117 | ENSMUSP00000145754 | Glucosamine-6-phosphate isomerase 2; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. | SH2B adapter protein 1; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphoryla [...] | 0.728 |
Kbtbd4 | Mtch2 | ENSMUSP00000107089 | ENSMUSP00000118566 | Kelch repeat and BTB domain-containing protein 4. | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.652 |
Kbtbd4 | Ndufs3 | ENSMUSP00000107089 | ENSMUSP00000005647 | Kelch repeat and BTB domain-containing protein 4. | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). | 0.663 |
Kbtbd4 | Ptpmt1 | ENSMUSP00000107089 | ENSMUSP00000159164 | Kelch repeat and BTB domain-containing protein 4. | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a [...] | 0.653 |
Kctd15 | Gnpda2 | ENSMUSP00000032709 | ENSMUSP00000031117 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity). | Glucosamine-6-phosphate isomerase 2; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. | 0.793 |
Kctd15 | Mtch2 | ENSMUSP00000032709 | ENSMUSP00000118566 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity). | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.740 |
Kctd15 | Negr1 | ENSMUSP00000032709 | ENSMUSP00000073664 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity). | Neuronal growth regulator 1; May be involved in cell-adhesion. May function as a trans- neural growth-promoting factor in regenerative axon sprouting in the mammalian brain. | 0.724 |
Kctd15 | Sec16b | ENSMUSP00000032709 | ENSMUSP00000083300 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity). | Protein transport protein Sec16B; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes; Belongs to the SEC16 family. | 0.760 |
Kctd15 | Sh2b1 | ENSMUSP00000032709 | ENSMUSP00000145754 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity). | SH2B adapter protein 1; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphoryla [...] | 0.724 |
Mtch2 | Bid | ENSMUSP00000118566 | ENSMUSP00000004560 | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c. | 0.665 |
Mtch2 | Gnpda2 | ENSMUSP00000118566 | ENSMUSP00000031117 | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | Glucosamine-6-phosphate isomerase 2; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. | 0.794 |
Mtch2 | Kbtbd4 | ENSMUSP00000118566 | ENSMUSP00000107089 | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | Kelch repeat and BTB domain-containing protein 4. | 0.652 |
Mtch2 | Kctd15 | ENSMUSP00000118566 | ENSMUSP00000032709 | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity). | 0.740 |
Mtch2 | Ndufs3 | ENSMUSP00000118566 | ENSMUSP00000005647 | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). | 0.769 |
Mtch2 | Negr1 | ENSMUSP00000118566 | ENSMUSP00000073664 | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | Neuronal growth regulator 1; May be involved in cell-adhesion. May function as a trans- neural growth-promoting factor in regenerative axon sprouting in the mammalian brain. | 0.759 |