STRINGSTRING
Gpatch8 protein (mouse) - STRING interaction network
"Gpatch8" - G patch domain containing 8 in Mus musculus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gpatch8G patch domain containing 8 (1505 aa)    
Predicted Functional Partners:
Prpf19
Pre-mRNA-processing factor 19; Isoform 1- Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys- 63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal co [...] (523 aa)
     
 
  0.732
Eftud2
116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP (By similarity) (972 aa)
     
 
  0.704
Kmt2c
Histone-lysine N-methyltransferase 2C; Histone methyltransferase. Methylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex (By similarity) (4904 aa)
     
        0.674
Srrm2
Serine/arginine repetitive matrix protein 2; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate. Binds to RNA (By similarity); Belongs to the CWC21 family (2607 aa)
     
   
  0.633
Dhx38
DEAH (Asp-Glu-Ala-His) box polypeptide 38 (1228 aa)
     
 
  0.622
Adprhl1
[Protein ADP-ribosylarginine] hydrolase-like protein 1; Seems not to catalyse the hydrolysis of O-acetyl-ADP- ribose (353 aa)
           
  0.606
Gm4782
Predicted gene 4782 (691 aa)
     
 
  0.605
Crnkl1
Crooked neck-like protein 1; Involved in pre-mRNA splicing process (690 aa)
     
 
  0.605
Ep300
Histone acetyltransferase p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (By similarity). Acetylates all four core histones in nucleosomes (By similarity). Histone acetylation gives an epigenetic tag for transcriptional activation (By similarity). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at ’Lys-122’ (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By [...] (2412 aa)
     
        0.599
Dqx1
ATP-dependent RNA helicase DQX1; DEAQ RNA-dependent ATPase (718 aa)
     
 
  0.578
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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