node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adgrl1 | Lrch2 | ENSMUSP00000118452 | ENSMUSP00000108438 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity); Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | 0.534 |
Adgrl2 | Lrch2 | ENSMUSP00000143626 | ENSMUSP00000108438 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | 0.534 |
Adgrl3 | Lrch2 | ENSMUSP00000072336 | ENSMUSP00000108438 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | 0.539 |
Dock8 | Lrch2 | ENSMUSP00000025831 | ENSMUSP00000108438 | Dedicator of cytokinesis protein 8; Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lyti [...] | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | 0.466 |
Eml3 | Lrch2 | ENSMUSP00000093960 | ENSMUSP00000108438 | Echinoderm microtubule-associated protein-like 3; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family. | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | 0.478 |
Erich6 | Lrch2 | ENSMUSP00000040882 | ENSMUSP00000108438 | Glutamate-rich protein 6; Belongs to the ERICH6 family. | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | 0.542 |
Erich6 | Ttc32 | ENSMUSP00000040882 | ENSMUSP00000082891 | Glutamate-rich protein 6; Belongs to the ERICH6 family. | Tetratricopeptide repeat protein 32. | 0.674 |
Lhfpl1 | Lrch2 | ENSMUSP00000044054 | ENSMUSP00000108438 | LHFPL tetraspan subfamily member 1 protein; Belongs to the LHFP family. | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | 0.454 |
Lrch2 | Adgrl1 | ENSMUSP00000108438 | ENSMUSP00000118452 | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity); Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | 0.534 |
Lrch2 | Adgrl2 | ENSMUSP00000108438 | ENSMUSP00000143626 | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. | 0.534 |
Lrch2 | Adgrl3 | ENSMUSP00000108438 | ENSMUSP00000072336 | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. | 0.539 |
Lrch2 | Dock8 | ENSMUSP00000108438 | ENSMUSP00000025831 | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | Dedicator of cytokinesis protein 8; Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lyti [...] | 0.466 |
Lrch2 | Eml3 | ENSMUSP00000108438 | ENSMUSP00000093960 | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | Echinoderm microtubule-associated protein-like 3; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family. | 0.478 |
Lrch2 | Erich6 | ENSMUSP00000108438 | ENSMUSP00000040882 | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | Glutamate-rich protein 6; Belongs to the ERICH6 family. | 0.542 |
Lrch2 | Lhfpl1 | ENSMUSP00000108438 | ENSMUSP00000044054 | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | LHFPL tetraspan subfamily member 1 protein; Belongs to the LHFP family. | 0.454 |
Lrch2 | Slain2 | ENSMUSP00000108438 | ENSMUSP00000115871 | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | SLAIN motif-containing protein 2; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. Belongs to the SLAIN motif-containing family. | 0.456 |
Lrch2 | Ttc32 | ENSMUSP00000108438 | ENSMUSP00000082891 | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | Tetratricopeptide repeat protein 32. | 0.548 |
Lrch2 | Zdhhc23 | ENSMUSP00000108438 | ENSMUSP00000156253 | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane (By similarity). | 0.460 |
Slain2 | Lrch2 | ENSMUSP00000115871 | ENSMUSP00000108438 | SLAIN motif-containing protein 2; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. Belongs to the SLAIN motif-containing family. | Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton. | 0.456 |
Ttc32 | Erich6 | ENSMUSP00000082891 | ENSMUSP00000040882 | Tetratricopeptide repeat protein 32. | Glutamate-rich protein 6; Belongs to the ERICH6 family. | 0.674 |