node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atp5j | Ccdc58 | ENSMUSP00000023608 | ENSMUSP00000125874 | ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of t [...] | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | 0.608 |
Atp5j | Mrpl30 | ENSMUSP00000023608 | ENSMUSP00000027256 | ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of t [...] | 39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family. | 0.571 |
Atp5j | Mrpl39 | ENSMUSP00000023608 | ENSMUSP00000112283 | ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of t [...] | 39S ribosomal protein L39, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL39 family. | 0.591 |
Atp5j | Ssbp1 | ENSMUSP00000023608 | ENSMUSP00000031971 | ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of t [...] | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.543 |
Ccdc58 | Atp5j | ENSMUSP00000125874 | ENSMUSP00000023608 | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of t [...] | 0.608 |
Ccdc58 | Ccdc87 | ENSMUSP00000125874 | ENSMUSP00000086028 | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | Coiled-coil domain-containing protein 87; Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility; Belongs to the CCDC87 family. | 0.659 |
Ccdc58 | Cstdc6 | ENSMUSP00000125874 | ENSMUSP00000110500 | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | Cystatin domain-containing 6. | 0.604 |
Ccdc58 | Fam162a | ENSMUSP00000125874 | ENSMUSP00000004057 | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | Protein FAM162A; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia- induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly; Belongs to the UPF0389 family. | 0.562 |
Ccdc58 | Mrpl30 | ENSMUSP00000125874 | ENSMUSP00000027256 | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | 39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family. | 0.604 |
Ccdc58 | Mrpl39 | ENSMUSP00000125874 | ENSMUSP00000112283 | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | 39S ribosomal protein L39, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL39 family. | 0.554 |
Ccdc58 | Mrps35 | ENSMUSP00000125874 | ENSMUSP00000048348 | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | 28S ribosomal protein S35, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS35 family. | 0.722 |
Ccdc58 | Ssbp1 | ENSMUSP00000125874 | ENSMUSP00000031971 | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.661 |
Ccdc58 | Timm9 | ENSMUSP00000125874 | ENSMUSP00000126298 | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | Mitochondrial import inner membrane translocase subunit Tim9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family. | 0.729 |
Ccdc58 | Vbp1 | ENSMUSP00000125874 | ENSMUSP00000033540 | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). | 0.621 |
Ccdc87 | Ccdc58 | ENSMUSP00000086028 | ENSMUSP00000125874 | Coiled-coil domain-containing protein 87; Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility; Belongs to the CCDC87 family. | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | 0.659 |
Cstdc6 | Ccdc58 | ENSMUSP00000110500 | ENSMUSP00000125874 | Cystatin domain-containing 6. | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | 0.604 |
Cstdc6 | Fam162a | ENSMUSP00000110500 | ENSMUSP00000004057 | Cystatin domain-containing 6. | Protein FAM162A; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia- induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly; Belongs to the UPF0389 family. | 0.406 |
Fam162a | Ccdc58 | ENSMUSP00000004057 | ENSMUSP00000125874 | Protein FAM162A; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia- induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly; Belongs to the UPF0389 family. | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | 0.562 |
Fam162a | Cstdc6 | ENSMUSP00000004057 | ENSMUSP00000110500 | Protein FAM162A; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia- induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly; Belongs to the UPF0389 family. | Cystatin domain-containing 6. | 0.406 |
Mrpl30 | Atp5j | ENSMUSP00000027256 | ENSMUSP00000023608 | 39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family. | ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of t [...] | 0.571 |