STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Smim7Small integral membrane protein 7. (75 aa)    
Predicted Functional Partners:
Cog3
Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport.
   
 
 0.877
Cog8
Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function.
   
 
 0.875
Cog6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
   
 
 0.867
Cog2
Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function.
   
 
 0.865
Cog5
Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function.
    
 
 0.825
Cog1
Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.
   
 
 0.821
Cog7
Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function.
   
 
 0.720
Tmem38a
Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
   
  
 0.685
Tpx2
Targeting protein for Xklp2; Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin- alpha, allowing TPX2 to activate [...]
    
 
 0.684
Scfd1
Sec1 family domain-containing protein 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity); Belongs to the STXBP/unc-18/SEC1 family.
   
 
 0.647
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.