node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc42 | Ccdc96 | ENSMUSP00000114381 | ENSMUSP00000059636 | Coiled-coil domain-containing protein 42; Required for sperm development. Belongs to the CFAP73 family. | Coiled-coil domain-containing protein 96. | 0.524 |
Ccdc42 | Hook1 | ENSMUSP00000114381 | ENSMUSP00000030306 | Coiled-coil domain-containing protein 42; Required for sperm development. Belongs to the CFAP73 family. | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | 0.552 |
Ccdc42 | Morn3 | ENSMUSP00000114381 | ENSMUSP00000031437 | Coiled-coil domain-containing protein 42; Required for sperm development. Belongs to the CFAP73 family. | MORN repeat-containing protein 3. | 0.484 |
Ccdc42 | Rimbp3 | ENSMUSP00000114381 | ENSMUSP00000127909 | Coiled-coil domain-containing protein 42; Required for sperm development. Belongs to the CFAP73 family. | RIMS-binding protein 3; Component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. Important for male fertility ; Belongs to the RIMBP family. | 0.581 |
Ccdc54 | Rimbp3 | ENSMUSP00000049864 | ENSMUSP00000127909 | Coiled-coil domain-containing protein 54. | RIMS-binding protein 3; Component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. Important for male fertility ; Belongs to the RIMBP family. | 0.606 |
Ccdc96 | Ccdc42 | ENSMUSP00000059636 | ENSMUSP00000114381 | Coiled-coil domain-containing protein 96. | Coiled-coil domain-containing protein 42; Required for sperm development. Belongs to the CFAP73 family. | 0.524 |
Ccdc96 | Heatr9 | ENSMUSP00000059636 | ENSMUSP00000019069 | Coiled-coil domain-containing protein 96. | Protein HEATR9. | 0.663 |
Ccdc96 | Rimbp3 | ENSMUSP00000059636 | ENSMUSP00000127909 | Coiled-coil domain-containing protein 96. | RIMS-binding protein 3; Component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. Important for male fertility ; Belongs to the RIMBP family. | 0.546 |
Heatr9 | Ccdc96 | ENSMUSP00000019069 | ENSMUSP00000059636 | Protein HEATR9. | Coiled-coil domain-containing protein 96. | 0.663 |
Heatr9 | Rimbp3 | ENSMUSP00000019069 | ENSMUSP00000127909 | Protein HEATR9. | RIMS-binding protein 3; Component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. Important for male fertility ; Belongs to the RIMBP family. | 0.573 |
Hook1 | Ccdc42 | ENSMUSP00000030306 | ENSMUSP00000114381 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | Coiled-coil domain-containing protein 42; Required for sperm development. Belongs to the CFAP73 family. | 0.552 |
Hook1 | Kif3b | ENSMUSP00000030306 | ENSMUSP00000028977 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | Kinesin-like protein KIF3B, N-terminally processed; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. | 0.527 |
Hook1 | Mapk8ip1 | ENSMUSP00000030306 | ENSMUSP00000050773 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | C-Jun-amino-terminal kinase-interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fu [...] | 0.469 |
Hook1 | Morn3 | ENSMUSP00000030306 | ENSMUSP00000031437 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | MORN repeat-containing protein 3. | 0.602 |
Hook1 | Rimbp3 | ENSMUSP00000030306 | ENSMUSP00000127909 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | RIMS-binding protein 3; Component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. Important for male fertility ; Belongs to the RIMBP family. | 0.900 |
Kif3b | Hook1 | ENSMUSP00000028977 | ENSMUSP00000030306 | Kinesin-like protein KIF3B, N-terminally processed; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | 0.527 |
Kif3b | Morn3 | ENSMUSP00000028977 | ENSMUSP00000031437 | Kinesin-like protein KIF3B, N-terminally processed; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. | MORN repeat-containing protein 3. | 0.523 |
Kif3b | Rimbp3 | ENSMUSP00000028977 | ENSMUSP00000127909 | Kinesin-like protein KIF3B, N-terminally processed; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. | RIMS-binding protein 3; Component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. Important for male fertility ; Belongs to the RIMBP family. | 0.755 |
Mapk8ip1 | Hook1 | ENSMUSP00000050773 | ENSMUSP00000030306 | C-Jun-amino-terminal kinase-interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fu [...] | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | 0.469 |
Mapk8ip1 | Mapk8ip2 | ENSMUSP00000050773 | ENSMUSP00000023291 | C-Jun-amino-terminal kinase-interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fu [...] | C-Jun-amino-terminal kinase-interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells (By similarity). | 0.986 |