node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1d | Cfap54 | ENSMUSP00000000594 | ENSMUSP00000148636 | Nuclear nucleic acid-binding protein C1D; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity); Belongs to the C1D family. | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | 0.683 |
C1d | Cfap74 | ENSMUSP00000000594 | ENSMUSP00000131899 | Nuclear nucleic acid-binding protein C1D; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity); Belongs to the C1D family. | Cilia- and flagella-associated protein 74; As part of the central apparatus of the cilium axoneme may play a role in cilium movement. | 0.477 |
C1d | Spag17 | ENSMUSP00000000594 | ENSMUSP00000134066 | Nuclear nucleic acid-binding protein C1D; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity); Belongs to the C1D family. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.552 |
C1d | Spag6 | ENSMUSP00000000594 | ENSMUSP00000092751 | Nuclear nucleic acid-binding protein C1D; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity); Belongs to the C1D family. | Sperm-associated antigen 6. | 0.499 |
C1d | Spag6l | ENSMUSP00000000594 | ENSMUSP00000023468 | Nuclear nucleic acid-binding protein C1D; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity); Belongs to the C1D family. | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. | 0.673 |
C1d | Spef2 | ENSMUSP00000000594 | ENSMUSP00000035762 | Nuclear nucleic acid-binding protein C1D; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity); Belongs to the C1D family. | Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation. | 0.607 |
Cfap221 | Cfap54 | ENSMUSP00000134576 | ENSMUSP00000148636 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. Belongs to the PCDP1 family. | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | 0.687 |
Cfap221 | Spag17 | ENSMUSP00000134576 | ENSMUSP00000134066 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. Belongs to the PCDP1 family. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.502 |
Cfap221 | Spag6 | ENSMUSP00000134576 | ENSMUSP00000092751 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. Belongs to the PCDP1 family. | Sperm-associated antigen 6. | 0.561 |
Cfap221 | Spag6l | ENSMUSP00000134576 | ENSMUSP00000023468 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. Belongs to the PCDP1 family. | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. | 0.601 |
Cfap221 | Spef2 | ENSMUSP00000134576 | ENSMUSP00000035762 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. Belongs to the PCDP1 family. | Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation. | 0.677 |
Cfap54 | C1d | ENSMUSP00000148636 | ENSMUSP00000000594 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | Nuclear nucleic acid-binding protein C1D; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity); Belongs to the C1D family. | 0.683 |
Cfap54 | Cfap221 | ENSMUSP00000148636 | ENSMUSP00000134576 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. Belongs to the PCDP1 family. | 0.687 |
Cfap54 | Cfap74 | ENSMUSP00000148636 | ENSMUSP00000131899 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | Cilia- and flagella-associated protein 74; As part of the central apparatus of the cilium axoneme may play a role in cilium movement. | 0.620 |
Cfap54 | Lrguk | ENSMUSP00000148636 | ENSMUSP00000065146 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | 0.681 |
Cfap54 | Spag17 | ENSMUSP00000148636 | ENSMUSP00000134066 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.633 |
Cfap54 | Spag6 | ENSMUSP00000148636 | ENSMUSP00000092751 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | Sperm-associated antigen 6. | 0.629 |
Cfap54 | Spag6l | ENSMUSP00000148636 | ENSMUSP00000023468 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. | 0.605 |
Cfap54 | Spef2 | ENSMUSP00000148636 | ENSMUSP00000035762 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation. | 0.807 |
Cfap54 | Tbx1 | ENSMUSP00000148636 | ENSMUSP00000156061 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | T-box transcription factor TBX1; Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries. | 0.606 |