node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Anxa2 | Myadm | ENSMUSP00000034756 | ENSMUSP00000145120 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | Myeloid-associated differentiation marker. | 0.515 |
Anxa2 | S100a6 | ENSMUSP00000034756 | ENSMUSP00000001051 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity); Belongs to the S-100 family. | 0.942 |
Arhgef40 | Myadm | ENSMUSP00000091331 | ENSMUSP00000145120 | Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF). | Myeloid-associated differentiation marker. | 0.484 |
Ccdc36 | Myadm | ENSMUSP00000075898 | ENSMUSP00000145120 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | Myeloid-associated differentiation marker. | 0.520 |
Cklf | Myadm | ENSMUSP00000034342 | ENSMUSP00000145120 | Chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. | Myeloid-associated differentiation marker. | 0.499 |
Cklf | Pllp | ENSMUSP00000034342 | ENSMUSP00000034227 | Chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). | 0.538 |
Cop1 | Myadm | ENSMUSP00000076160 | ENSMUSP00000145120 | E3 ubiquitin-protein ligase COP1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity [...] | Myeloid-associated differentiation marker. | 0.504 |
Myadm | Anxa2 | ENSMUSP00000145120 | ENSMUSP00000034756 | Myeloid-associated differentiation marker. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | 0.515 |
Myadm | Arhgef40 | ENSMUSP00000145120 | ENSMUSP00000091331 | Myeloid-associated differentiation marker. | Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF). | 0.484 |
Myadm | Ccdc36 | ENSMUSP00000145120 | ENSMUSP00000075898 | Myeloid-associated differentiation marker. | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | 0.520 |
Myadm | Cklf | ENSMUSP00000145120 | ENSMUSP00000034342 | Myeloid-associated differentiation marker. | Chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. | 0.499 |
Myadm | Cop1 | ENSMUSP00000145120 | ENSMUSP00000076160 | Myeloid-associated differentiation marker. | E3 ubiquitin-protein ligase COP1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity [...] | 0.504 |
Myadm | Olfr1239 | ENSMUSP00000145120 | ENSMUSP00000150225 | Myeloid-associated differentiation marker. | Olfactory receptor. | 0.485 |
Myadm | Pllp | ENSMUSP00000145120 | ENSMUSP00000034227 | Myeloid-associated differentiation marker. | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). | 0.602 |
Myadm | S100a6 | ENSMUSP00000145120 | ENSMUSP00000001051 | Myeloid-associated differentiation marker. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity); Belongs to the S-100 family. | 0.520 |
Myadm | Tagap | ENSMUSP00000145120 | ENSMUSP00000047431 | Myeloid-associated differentiation marker. | T-cell activation Rho GTPase-activating protein; May function as a GTPase-activating protein. May play a role in transmission ratio distortion (TRD) in mouse, in which heterozygous males for t-locus transmit their t-carrying chromosome to 95% or more of their offspring. | 0.529 |
Myadm | Wfdc13 | ENSMUSP00000145120 | ENSMUSP00000085594 | Myeloid-associated differentiation marker. | WAP four-disulfide core domain protein 13; Putative acid-stable proteinase inhibitor. | 0.465 |
Olfr1239 | Myadm | ENSMUSP00000150225 | ENSMUSP00000145120 | Olfactory receptor. | Myeloid-associated differentiation marker. | 0.485 |
Pllp | Cklf | ENSMUSP00000034227 | ENSMUSP00000034342 | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). | Chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. | 0.538 |
Pllp | Myadm | ENSMUSP00000034227 | ENSMUSP00000145120 | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). | Myeloid-associated differentiation marker. | 0.602 |