node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arl15 | Cnnm1 | ENSMUSP00000088740 | ENSMUSP00000131830 | ADP-ribosylation factor-like protein 15; Belongs to the small GTPase superfamily. Arf family. | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | 0.471 |
Arl15 | Ptp4a1 | ENSMUSP00000088740 | ENSMUSP00000027232 | ADP-ribosylation factor-like protein 15; Belongs to the small GTPase superfamily. Arf family. | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). | 0.563 |
Cbs | Cnnm1 | ENSMUSP00000158269 | ENSMUSP00000131830 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | 0.591 |
Cbs | Mrs2 | ENSMUSP00000158269 | ENSMUSP00000021772 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | 0.405 |
Cnnm1 | Arl15 | ENSMUSP00000131830 | ENSMUSP00000088740 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | ADP-ribosylation factor-like protein 15; Belongs to the small GTPase superfamily. Arf family. | 0.471 |
Cnnm1 | Cbs | ENSMUSP00000131830 | ENSMUSP00000158269 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | 0.591 |
Cnnm1 | Mrs2 | ENSMUSP00000131830 | ENSMUSP00000021772 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | 0.496 |
Cnnm1 | Nipa1 | ENSMUSP00000131830 | ENSMUSP00000053871 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+); Belongs to the NIPA family. | 0.478 |
Cnnm1 | Ptp4a1 | ENSMUSP00000131830 | ENSMUSP00000027232 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). | 0.490 |
Cnnm1 | Slc41a1 | ENSMUSP00000131830 | ENSMUSP00000083747 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance; Belongs to the SLC41A transporter family. | 0.667 |
Cnnm1 | Slc41a2 | ENSMUSP00000131830 | ENSMUSP00000036690 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Solute carrier family 41 member 2; Acts as a plasma-membrane magnesium transporter. Belongs to the SLC41A transporter family. | 0.642 |
Cnnm1 | Slc41a3 | ENSMUSP00000131830 | ENSMUSP00000037473 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Solute carrier family 41 member 3; Belongs to the SLC41A transporter family. | 0.528 |
Cnnm1 | Trpm6 | ENSMUSP00000131830 | ENSMUSP00000037443 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Transient receptor potential cation channel subfamily M member 6; Essential ion channel and kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney (By similarity); In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily. | 0.730 |
Cnnm1 | Trpm7 | ENSMUSP00000131830 | ENSMUSP00000099513 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Transient receptor potential cation channel subfamily M member 7; Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A [...] | 0.584 |
Mrs2 | Cbs | ENSMUSP00000021772 | ENSMUSP00000158269 | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | 0.405 |
Mrs2 | Cnnm1 | ENSMUSP00000021772 | ENSMUSP00000131830 | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | 0.496 |
Mrs2 | Nipa1 | ENSMUSP00000021772 | ENSMUSP00000053871 | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+); Belongs to the NIPA family. | 0.402 |
Mrs2 | Slc41a1 | ENSMUSP00000021772 | ENSMUSP00000083747 | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance; Belongs to the SLC41A transporter family. | 0.689 |
Mrs2 | Slc41a2 | ENSMUSP00000021772 | ENSMUSP00000036690 | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | Solute carrier family 41 member 2; Acts as a plasma-membrane magnesium transporter. Belongs to the SLC41A transporter family. | 0.703 |
Mrs2 | Slc41a3 | ENSMUSP00000021772 | ENSMUSP00000037473 | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | Solute carrier family 41 member 3; Belongs to the SLC41A transporter family. | 0.713 |