STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Dnajc28DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone. (409 aa)    
Predicted Functional Partners:
Dnajc9
DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.
      
 0.628
Tmem50b
Transmembrane protein 50B; Belongs to the UPF0220 family.
      
 0.580
Fam120c
Constitutive coactivator of PPAR-gamma-like protein 2.
   
  
 0.570
Dnajc25
DnaJ homolog subfamily C member 25; Belongs to the DNAJC25 family.
      
 0.563
Kctd21
BTB/POZ domain-containing protein KCTD21; Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB).
   
  
 0.561
Dnajc27
DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; Belongs to the small GTPase superfamily. Rab family.
   
  
 0.548
Cog6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
   
 
  0.548
Cog5
Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function.
   
 
  0.546
Cog4
Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.
   
 
  0.543
Cog2
Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function.
   
 
  0.542
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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