node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abcb11 | Tmem14a | ENSMUSP00000099770 | ENSMUSP00000027064 | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family. | 0.432 |
Abcb11 | Tmem205 | ENSMUSP00000099770 | ENSMUSP00000158874 | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | Transmembrane protein 205. | 0.460 |
Ccdc159 | Tmem205 | ENSMUSP00000126474 | ENSMUSP00000158874 | Coiled-coil domain-containing protein 159. | Transmembrane protein 205. | 0.539 |
Efr3b | Gramd1c | ENSMUSP00000106809 | ENSMUSP00000036739 | Protein EFR3 homolog B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3B probably acts as the membrane-anchoring component. Also involved in responsiveness to G- protein-coupled receptors; it is however unclear whether this role is direct or indirect. | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | 0.448 |
Efr3b | Tmem205 | ENSMUSP00000106809 | ENSMUSP00000158874 | Protein EFR3 homolog B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3B probably acts as the membrane-anchoring component. Also involved in responsiveness to G- protein-coupled receptors; it is however unclear whether this role is direct or indirect. | Transmembrane protein 205. | 0.450 |
Efr3b | Ttc9 | ENSMUSP00000106809 | ENSMUSP00000152038 | Protein EFR3 homolog B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3B probably acts as the membrane-anchoring component. Also involved in responsiveness to G- protein-coupled receptors; it is however unclear whether this role is direct or indirect. | Tetratricopeptide repeat protein 9A; Belongs to the TTC9 family. | 0.427 |
Efr3b | Wdr17 | ENSMUSP00000106809 | ENSMUSP00000117710 | Protein EFR3 homolog B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3B probably acts as the membrane-anchoring component. Also involved in responsiveness to G- protein-coupled receptors; it is however unclear whether this role is direct or indirect. | WD repeat domain 17. | 0.444 |
Gramd1c | Efr3b | ENSMUSP00000036739 | ENSMUSP00000106809 | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | Protein EFR3 homolog B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3B probably acts as the membrane-anchoring component. Also involved in responsiveness to G- protein-coupled receptors; it is however unclear whether this role is direct or indirect. | 0.448 |
Gramd1c | Mslnl | ENSMUSP00000036739 | ENSMUSP00000049020 | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | Mesothelin-like protein; May play a role in cellular adhesion; Belongs to the mesothelin family. | 0.454 |
Gramd1c | Tmem205 | ENSMUSP00000036739 | ENSMUSP00000158874 | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | Transmembrane protein 205. | 0.506 |
Gramd1c | Ttc9 | ENSMUSP00000036739 | ENSMUSP00000152038 | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | Tetratricopeptide repeat protein 9A; Belongs to the TTC9 family. | 0.495 |
Gramd1c | Wdr17 | ENSMUSP00000036739 | ENSMUSP00000117710 | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | WD repeat domain 17. | 0.488 |
Mslnl | Gramd1c | ENSMUSP00000049020 | ENSMUSP00000036739 | Mesothelin-like protein; May play a role in cellular adhesion; Belongs to the mesothelin family. | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | 0.454 |
Mslnl | Tmem205 | ENSMUSP00000049020 | ENSMUSP00000158874 | Mesothelin-like protein; May play a role in cellular adhesion; Belongs to the mesothelin family. | Transmembrane protein 205. | 0.456 |
Mslnl | Ttc9 | ENSMUSP00000049020 | ENSMUSP00000152038 | Mesothelin-like protein; May play a role in cellular adhesion; Belongs to the mesothelin family. | Tetratricopeptide repeat protein 9A; Belongs to the TTC9 family. | 0.455 |
Mslnl | Wdr17 | ENSMUSP00000049020 | ENSMUSP00000117710 | Mesothelin-like protein; May play a role in cellular adhesion; Belongs to the mesothelin family. | WD repeat domain 17. | 0.447 |
Ocel1 | Tmem205 | ENSMUSP00000002469 | ENSMUSP00000158874 | Occludin/ELL domain-containing protein 1; Belongs to the ELL/occludin family. | Transmembrane protein 205. | 0.534 |
Rab8a | Tmem205 | ENSMUSP00000003121 | ENSMUSP00000158874 | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | Transmembrane protein 205. | 0.451 |
Tmem14a | Abcb11 | ENSMUSP00000027064 | ENSMUSP00000099770 | Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family. | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | 0.432 |
Tmem14a | Tmem205 | ENSMUSP00000027064 | ENSMUSP00000158874 | Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family. | Transmembrane protein 205. | 0.651 |