node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ano2 | Ano3 | ENSMUSP00000125303 | ENSMUSP00000097219 | Anoctamin-2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor- sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. Belongs to the anoctamin family. | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity. | 0.640 |
Ano2 | Ano7 | ENSMUSP00000125303 | ENSMUSP00000140438 | Anoctamin-2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor- sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. Belongs to the anoctamin family. | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | 0.504 |
Ano2 | Clca3a1 | ENSMUSP00000125303 | ENSMUSP00000054526 | Anoctamin-2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor- sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. Belongs to the anoctamin family. | Calcium-activated chloride channel regulator 3A-1; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner. | 0.850 |
Ano3 | Ano2 | ENSMUSP00000097219 | ENSMUSP00000125303 | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity. | Anoctamin-2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor- sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. Belongs to the anoctamin family. | 0.640 |
Ano3 | Ano7 | ENSMUSP00000097219 | ENSMUSP00000140438 | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity. | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | 0.430 |
Ano3 | Clca3a1 | ENSMUSP00000097219 | ENSMUSP00000054526 | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity. | Calcium-activated chloride channel regulator 3A-1; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner. | 0.490 |
Ano7 | Ano2 | ENSMUSP00000140438 | ENSMUSP00000125303 | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | Anoctamin-2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor- sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. Belongs to the anoctamin family. | 0.504 |
Ano7 | Ano3 | ENSMUSP00000140438 | ENSMUSP00000097219 | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity. | 0.430 |
Ano7 | Brox | ENSMUSP00000140438 | ENSMUSP00000061345 | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | BRO1 domain-containing protein BROX. | 0.439 |
Ano7 | Calhm2 | ENSMUSP00000140438 | ENSMUSP00000047278 | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | Calcium homeostasis modulator protein 2; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | 0.473 |
Ano7 | Clca3a1 | ENSMUSP00000140438 | ENSMUSP00000054526 | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | Calcium-activated chloride channel regulator 3A-1; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner. | 0.535 |
Ano7 | Dact2 | ENSMUSP00000140438 | ENSMUSP00000051638 | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | Dapper homolog 2; Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling. | 0.437 |
Ano7 | Nop53 | ENSMUSP00000140438 | ENSMUSP00000043981 | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription (By similarity). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and all [...] | 0.403 |
Ano7 | Rhbdd2 | ENSMUSP00000140438 | ENSMUSP00000049060 | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | Rhomboid domain-containing protein 2. | 0.511 |
Ano7 | Thap4 | ENSMUSP00000140438 | ENSMUSP00000140761 | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | THAP domain-containing protein 4. | 0.459 |
Ano7 | Tmem44 | ENSMUSP00000140438 | ENSMUSP00000123494 | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | Transmembrane protein 44. | 0.524 |
Brox | Ano7 | ENSMUSP00000061345 | ENSMUSP00000140438 | BRO1 domain-containing protein BROX. | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | 0.439 |
Brox | Nop53 | ENSMUSP00000061345 | ENSMUSP00000043981 | BRO1 domain-containing protein BROX. | Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription (By similarity). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and all [...] | 0.496 |
Brox | Rhbdd2 | ENSMUSP00000061345 | ENSMUSP00000049060 | BRO1 domain-containing protein BROX. | Rhomboid domain-containing protein 2. | 0.531 |
Calhm2 | Ano7 | ENSMUSP00000047278 | ENSMUSP00000140438 | Calcium homeostasis modulator protein 2; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity). Belongs to the anoctamin family. | 0.473 |