STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gpr22G-protein coupled receptor 22; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (By similarity). May be involved in ciliogenesis (By similarity). (469 aa)    
Predicted Functional Partners:
Dus4l
tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus4 subfamily.
      
 0.721
Cog5
Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function.
   
  
 0.703
Bcap29
B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8- mediated apoptosis (By similarity); Belongs to the BCAP29/BCAP31 family.
      
 0.621
Zfp606
Zinc finger protein 606.
      
 0.553
Ccdc174
Coiled-coil domain-containing protein 174; Probably involved in neuronal development.
      
 0.533
1110059G10Rik
Uncharacterized protein KIAA1143 homolog.
      
 0.528
Gpr142
Probable G-protein coupled receptor 142; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.519
Mcf2l
Guanine nucleotide exchange factor DBS; Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N- terminus (By similarity).
   
  
 0.518
Gpr162
Probable G-protein coupled receptor 162; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.499
Gpr63
Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.
      
 0.477
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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