STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cmtm2aCKLF-like MARVEL transmembrane domain-containing protein 2A; Belongs to the chemokine-like factor family. (169 aa)    
Predicted Functional Partners:
Cklf
Chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle.
   
  
 0.651
Cmtm3
CKLF-like MARVEL transmembrane domain-containing protein 3.
 
    
 0.627
Prss37
Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system (By similarity).
   
  
 0.590
Cmtm4
CKLF-like MARVEL transmembrane domain-containing protein 4; Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD- L1/CD274 from being polyubiquitinated and targeted for degradation.
      
 0.559
Cmtm1
CKLF-like MARVEL transmembrane domain-containing 1.
   
  
 0.555
Adam3
A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct.
   
  
 0.551
Rnase10
Inactive ribonuclease-like protein 10; Secreted proximal epididymal protein required for post- testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity.
   
  
 0.545
Pate8
Secreted TFP/Ly-6/uPAR protein PATE-G.
      
 0.491
Pate10
Secreted TFP/Ly-6/uPAR protein PATE-N.
      
 0.489
Pdilt
Protein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis.
   
  
 0.478
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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