STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ms4a6cMembrane-spanning 4-domains subfamily A member 6C; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family. (217 aa)    
Predicted Functional Partners:
Ms4a6b
Membrane-spanning 4-domains subfamily A member 6B; May be involved in signal transduction as a component of a multimeric receptor complex.
  
  
0.685
Ms4a7
Membrane-spanning 4-domains, subfamily A, member 7.
   
  
0.682
Ms4a4c
Membrane-spanning 4-domains, subfamily A, member 4C.
   
  
0.682
Gm8369
Predicted gene 8369.
   
  
 0.644
Ms4a6d
Membrane-spanning 4-domains subfamily A member 6D; May be involved in signal transduction as a component of a multimeric receptor complex.
  
  
0.598
Fcgr1
High affinity immunoglobulin gamma Fc receptor I; High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
   
    0.555
Clec4a3
C-type lectin domain family 4, member a3.
   
  
 0.550
Igsf6
Immunoglobulin superfamily member 6.
   
  
 0.536
Mpeg1
Macrophage-expressed gene 1 protein; Plays a key role in the innate immune response following bacterial infection by polymerizing and inserting into the bacterial surface to form pores. By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence. Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogene [...]
   
  
 0.514
Aif1
Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
   
  
 0.492
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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