STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Irs1Insulin receptor substrate 1. (1230 aa)    
Predicted Functional Partners:
Grb2
Growth factor receptor bound protein 2.
    
 0.999
Pik3r1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.999
Igf1r
Insulin-like growth factor I receptor.
    
 0.998
Ins1
Insulin I.
     
 0.997
Ins2
Insulin II.
     
 0.997
Ptpn11
Protein tyrosine phosphatase, non-receptor type 11.
    
 0.995
Insr
Insulin receptor.
    
 0.995
Irs2
Insulin receptor substrate 2.
    
0.988
Pik3ca
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha.
    
 0.986
Ptpn1
Protein tyrosine phosphatase, non-receptor type 1.
    
 0.982
Your Current Organism:
Mus spretus
NCBI taxonomy Id: 10096
Other names: Algerian mouse, M. spretus, Mus musculus spretus, western wild mouse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.