STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Spry1Sprouty RTK signaling antagonist 1. (313 aa)    
Predicted Functional Partners:
Grb2
Growth factor receptor bound protein 2.
    
 
 0.911
Cbl
Casitas B-lineage lymphoma.
    
 0.840
Spry4
Sprouty RTK signaling antagonist 4.
   
0.736
Cblc
Casitas B-lineage lymphoma c.
    
 0.710
Egfr
Epidermal growth factor receptor.
     
 0.708
Spry2
Sprouty RTK signaling antagonist 2.
  
0.696
Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 
 0.694
Egf
Epidermal growth factor.
     
 0.652
Sos2
SOS Ras/Rho guanine nucleotide exchange factor 2.
    
 
 0.643
Sh3kbp1
SH3-domain kinase binding protein 1.
    
  0.630
Your Current Organism:
Mus spretus
NCBI taxonomy Id: 10096
Other names: Algerian mouse, M. spretus, Mus musculus spretus, western wild mouse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.