STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PdhC_12-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). (474 aa)    
Predicted Functional Partners:
SucA
2-oxoglutarate dehydrogenase E1 component.
 0.999
PdhB
Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component.
 
 0.998
Lpd
Dihydrolipoamide dehydrogenase.
 0.997
SDL75714.1
Dihydrolipoamide dehydrogenase.
 0.996
BfmBAB
Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 0.977
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.974
sucD
succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.968
pdhA
Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.937
SucB
2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
  
  
 
0.920
SDL39547.1
glutaryl-CoA dehydrogenase.
   
  0.917
Your Current Organism:
Sphingobacterium mizutaii
NCBI taxonomy Id: 1010
Other names: ATCC 33299, CCUG 15907, CDC group II-I, CIP 101122, DSM 11724, Flavibacterium mizutaii, Flavobacterium mizutaii, IFO 14946, JCM 21155, LMG 8340, LMG:8340, NBRC 14946, NCTC 12149, S. mizutaii, Sphingobacterium mizutae, Sphingobacterium sp. CCUG 15262, Sphingobacterium sp. CDC D3663, Sphingobacterium sp. LMG 8346, strain KC1794
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