Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Shc2SHC (Src homology 2 domain containing) transforming protein 2. (573 aa)    
Predicted Functional Partners:
Egfr
Epidermal growth factor receptor.
    
 0.993
Kdr
Kinase insert domain protein receptor.
    
 0.989
Erbb4
Erb-b2 receptor tyrosine kinase 4.
    
 0.968
Erbb2
Erb-b2 receptor tyrosine kinase 2.
    
 0.968
Flt1
FMS-like tyrosine kinase 1.
    
 0.963
Igf1r
Insulin-like growth factor I receptor.
    
 0.962
Erbb3
Erb-b2 receptor tyrosine kinase 3.
    
 0.956
Flt4
FMS-like tyrosine kinase 4.
    
 0.956
Gab1
Growth factor receptor bound protein 2-associated protein 1.
    
 0.951
Ntrk2
Neurotrophic tyrosine kinase, receptor, type 2.
    
 0.947
Your Current Organism:
Mus spicilegus
NCBI taxonomy Id: 10103
Other names: M. spicilegus, Mus hortulanus, mound-building mouse, steppe mouse
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