Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
E2f1E2F transcription factor 1. (430 aa)    
Predicted Functional Partners:
Rb1
RB transcriptional corepressor 1.
   
 0.998
Ccna2
Cyclin A2.
   
 0.996
Tfdp2
Transcription factor Dp 2.
   
 0.995
Cdk2
Cyclin-dependent kinase 2.
    
 0.994
Rbl1
RB transcriptional corepressor like 1.
   
 0.994
Cdk3
Cyclin-dependent kinase 3.
    
 0.994
Ccna1
Cyclin A1.
   
 0.990
Skp2
S-phase kinase-associated protein 2 (p45).
    
 0.988
Rbl2
RB transcriptional corepressor like 2.
   
 0.984
E2f4
E2F transcription factor 4.
  
 
0.983
Your Current Organism:
Mus spicilegus
NCBI taxonomy Id: 10103
Other names: M. spicilegus, Mus hortulanus, mound-building mouse, steppe mouse
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