STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TDP1Tyrosyl-DNA phosphodiesterase 1. (496 aa)    
Predicted Functional Partners:
top1
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
    
 
 0.923
A0J61_08243
WLM domain-containing protein.
    
 
 0.807
ku80
ATP-dependent DNA helicase II subunit 2.
    
 0.803
mph1_1
ATP-dependent DNA helicase mph1.
   
 
 0.797
ku70
ATP-dependent DNA helicase II subunit 1.
     
 0.791
cdc17
DNA ligase.
   
 
 0.771
MUS81
Crossover junction endonuclease MUS81.
   
 
 0.771
LIG4
DNA ligase 4; Belongs to the ATP-dependent DNA ligase family.
   
 
 0.769
rad16
DNA repair protein rad16.
   
 
 0.733
pso2
DNA cross-link repair protein pso2/snm1.
   
 
 0.649
Your Current Organism:
Choanephora cucurbitarum
NCBI taxonomy Id: 101091
Other names: C. cucurbitarum, Choanephora infundibulifera f. cucurbitarum
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