STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
atg4bCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. (503 aa)    
Predicted Functional Partners:
ATG8_1
Autophagy-related protein.
   
 0.996
ATG8_0
Autophagy-related protein.
   
 0.987
ATG1
Serine/threonine-protein kinase ATG1; Belongs to the protein kinase superfamily.
   
 
 0.984
atg15_1
Putative lipase atg15.
   
 
 0.936
atg15_0
Putative lipase atg15.
   
 
 0.936
atg3
Autophagy-related protein 3.
   
 
 0.803
ATG18
Autophagy-related protein 18.
   
 
 0.764
ATG7
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...]
   
 
 0.720
atg13
Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily.
   
 
 0.699
ATG12
Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.
   
 
 0.631
Your Current Organism:
Choanephora cucurbitarum
NCBI taxonomy Id: 101091
Other names: C. cucurbitarum, Choanephora infundibulifera f. cucurbitarum
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.