STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RT1-BaRano class II histocompatibility antigen, B alpha chain. (255 aa)    
Predicted Functional Partners:
RT1-Db1
Rano class II histocompatibility antigen, D-1 beta chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class II family.
   
0.999
RT1-Bb
Rano class II histocompatibility antigen, B-1 beta chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class II family.
   
0.999
Cd74
H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44.
   
 0.998
RT1-DOb
RT1 class II, locus DOb.
   
0.945
Cd4
T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]
   
 
 0.918
LOC688340
T-cell receptor alpha chain V region PHDS58-like.
    
  0.910
RT1-Da
Histocompatibility 2, class II antigen E alpha; Belongs to the MHC class II family.
  
 
0.902
RT1-CE5
RT1 class I, locus CE5; Belongs to the MHC class I family.
   
 0.882
RT1-DMb
Major histocompatibility complex, class II, DM beta, isoform CRA_a.
   
0.865
LOC100909630
RT1 class II, locus DMb.
   
0.863
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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