STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103694381Lymphotoxin beta (TNF superfamily, member 3); Belongs to the tumor necrosis factor family. (306 aa)    
Predicted Functional Partners:
Lta
Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
   
 0.999
Ltbr
Lymphotoxin beta receptor (TNFR superfamily, member 3).
   
 0.998
Tnfsf13b
Similar to NZB B-cell activating factor (Predicted), isoform CRA_b; Belongs to the tumor necrosis factor family.
   
 
 0.826
Cd40lg
CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]
   
 
 0.803
Cd40
Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a.
   
 0.789
Tnfsf14
Similar to Tumor necrosis factor ligand superfamily member 14 (CD258 antigen).
   
 0.747
Ccr7
Chemokine receptor 7-like protein; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.743
Tnfsf12
Tumor necrosis factor ligand superfamily member 12; Belongs to the tumor necrosis factor family.
     
 0.737
Relb
RELB proto-oncogene, NF-kB subunit.
   
  
 0.714
Map3k14
Mitogen-activated protein kinase kinase kinase 14 (Predicted), isoform CRA_a.
   
 
 0.686
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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