node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Snap23 | Stx11 | ENSRNOP00000064401 | ENSRNOP00000073255 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family. | Syntaxin 11; Belongs to the syntaxin family. | 0.953 |
Snap23 | Stx1a | ENSRNOP00000064401 | ENSRNOP00000040699 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family. | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.992 |
Snap23 | Stx2 | ENSRNOP00000064401 | ENSRNOP00000001242 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family. | Syntaxin-2; Essential for epithelial morphogenesis. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm. | 0.968 |
Snap23 | Stx3 | ENSRNOP00000064401 | ENSRNOP00000028535 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family. | Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones. | 0.996 |
Snap23 | Stx4 | ENSRNOP00000064401 | ENSRNOP00000074754 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family. | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones. | 0.999 |
Snap23 | Stxbp2 | ENSRNOP00000064401 | ENSRNOP00000001322 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family. | Syntaxin-binding protein 2; Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells (By similarity); Belongs to the STXBP/unc-18/SEC1 family. | 0.835 |
Snap23 | Unc13d | ENSRNOP00000064401 | ENSRNOP00000010466 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family. | Protein unc-13 homolog D; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)- dependent secretory lysosome exocytosis in mast cells (By similarity). | 0.542 |
Snap23 | Vamp2 | ENSRNOP00000064401 | ENSRNOP00000054114 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family. | Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane (Probable). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 ; Belongs to the synaptobrevin family. | 0.999 |
Snap23 | Vamp3 | ENSRNOP00000064401 | ENSRNOP00000048364 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family. | Vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the synaptobrevin family. | 0.999 |
Snap23 | Vamp8 | ENSRNOP00000064401 | ENSRNOP00000017301 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family. | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex (By similarity). Also required for dense-granule secretion in plat [...] | 0.999 |
Stx11 | Snap23 | ENSRNOP00000073255 | ENSRNOP00000064401 | Syntaxin 11; Belongs to the syntaxin family. | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family. | 0.953 |
Stx11 | Stx1a | ENSRNOP00000073255 | ENSRNOP00000040699 | Syntaxin 11; Belongs to the syntaxin family. | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.567 |
Stx11 | Stx2 | ENSRNOP00000073255 | ENSRNOP00000001242 | Syntaxin 11; Belongs to the syntaxin family. | Syntaxin-2; Essential for epithelial morphogenesis. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm. | 0.582 |
Stx11 | Stx3 | ENSRNOP00000073255 | ENSRNOP00000028535 | Syntaxin 11; Belongs to the syntaxin family. | Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones. | 0.678 |
Stx11 | Stx4 | ENSRNOP00000073255 | ENSRNOP00000074754 | Syntaxin 11; Belongs to the syntaxin family. | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones. | 0.615 |
Stx11 | Stxbp2 | ENSRNOP00000073255 | ENSRNOP00000001322 | Syntaxin 11; Belongs to the syntaxin family. | Syntaxin-binding protein 2; Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells (By similarity); Belongs to the STXBP/unc-18/SEC1 family. | 0.966 |
Stx11 | Unc13d | ENSRNOP00000073255 | ENSRNOP00000010466 | Syntaxin 11; Belongs to the syntaxin family. | Protein unc-13 homolog D; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)- dependent secretory lysosome exocytosis in mast cells (By similarity). | 0.920 |
Stx11 | Vamp2 | ENSRNOP00000073255 | ENSRNOP00000054114 | Syntaxin 11; Belongs to the syntaxin family. | Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane (Probable). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 ; Belongs to the synaptobrevin family. | 0.922 |
Stx11 | Vamp3 | ENSRNOP00000073255 | ENSRNOP00000048364 | Syntaxin 11; Belongs to the syntaxin family. | Vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the synaptobrevin family. | 0.905 |
Stx11 | Vamp8 | ENSRNOP00000073255 | ENSRNOP00000017301 | Syntaxin 11; Belongs to the syntaxin family. | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex (By similarity). Also required for dense-granule secretion in plat [...] | 0.969 |